桑蒺合剂干预高血压病（肝火亢盛夹痰证）患者外周血单核细胞表面TLR4表达

目的：评价桑蒺合剂干预高血压病（肝火亢盛夹痰证）患者外周血单核细胞表面 Toll 样受体4（TLR4）表达的作用。方法：60例高血压肝火亢盛夹痰证患者，随机分为治疗组和对照组各30例，均给予非洛地平或联合贝那普利治疗，治疗组加用桑蒺合剂，观察周期28天，检测治疗前后血压、中医证候积分、外周血单核细胞表面TLR4表达。结果：治疗后两组患者血压水平、中医证候积分、TLR4表达均较治疗前降低，其中治疗组中医证候积分、TLR4表达较对照组改变更明显（P〈0.05）。结论：桑蒺合剂可改善肝火亢盛夹痰证患者的临床症状，减少外周血单核细胞表面TLR4表达，在一定程度上可以抑制免疫反应。

Study on Intervention Effect of Sang-Ji Mixture in TLR-4 Expression on Peripheral Blood Monocytes in Hypertensive Patients with Overabundant Liver-fire and Phlegm Syndrome

This study was aimed to observe the effect of Sang-Ji （SJ） mixture in the treatment of Toll-like receptor 4 （TLR-4） expression on peripheral blood monocytes （PBMCs） in hypertensive patients. A total of 60 cases of hyper-tensive cases with overabundant liver-fire and phlegm syndrome were randomly divided into the treatment group and the control group with 30 cases in each group. Both groups received Felodipine and/or Benazapril treat-ment. The treatment group was added with SJ mixture. The observation duration was 28 days. The detection was made on indicators such as blood pressure , traditional Chinese medicine （ TCM ） syndrome scores and TLR-4 ex-pression on PBMCs before and after treatment. The results showed that after treatment, the blood pressure, TCM＆amp;nbsp;syndrome scores and TLR-4 expression on PBMCs of both groups decreased compared with that of the pretreat-ment . Changes on TCM syndrome scores and TLR-4 expression of the treatment group were more significant than that of the control group （ P 〈 0 . 05 ） . It was concluded that SJ mixture improved clinical symptoms in pa-tients with overabundant liver-fire and phlegm syndrome , decreased TLR-4 expression on PBMCs , in order to inhibit the immune response to a certain extent .