IL-5、ET及CGRP在变应性鼻炎中的表达

目的：测定变应性鼻炎（allergic rhinitis,AR）患者血中白细胞介素-5（IL-5）、内皮素（ET）及降钙素基因相关肽（CGRP）水平的变化,观察它们在变应性鼻炎中的作用及相互关系,为变应性鼻炎的发病机制、发展及治疗提供依据。方法：选择变应性鼻炎患者36例,慢性鼻-鼻窦炎（chronic rhinosinusitis,CRS）32例,健康对照组30例。分别测定血清IL-5、血浆ET及CGRP水平。结果：IL-5、ET及CGRP含量在变应性鼻炎患者血中较慢性鼻-鼻窦炎患者有明显增高,IL-5、ET及CGRP含量分别为（88.25±33.47）、（77.81±8.26）、（45.32±7.35）ng/L,显著高于慢性鼻-鼻窦炎组[（44.34±16.32）、（72.53±8.34）、（40.07±7.13）ng/L]及健康对照组[（31.24±8.43）、（66.12±7.73）、（35.53±8.02）ng/L]。慢性鼻-鼻窦炎与健康对照组比较亦有明显差异。结论：IL-5、ET及CGRP在变应性鼻炎患者血液中含量较高,它们可能参与了变应性鼻炎的病理生理过程,其变化可能与变应性鼻炎的发生、发展有关。

Expression of interleukin-5, endothelin and calcitionin gene-related peptide in allergic rhinitis

Objective：To detect expression of interleukin-5,endothelin and calcitonin gene-related peptide in the blood of allergic rhinitis（AR） patients,and observe the relationship between them.Methods：36 cases with AR,32 cases with CRS and 30 healthy individual served as control group.The levels of interleukin-5 and ET and CGRP were measured and analyzed.Results：IL-5 and ET and CGRP levels [（88.25±33.47）、（77.81±8.26）、（45.32±7.35） ng/L]were significantly higher in AR than in CRS [（44.34 ±16.32）、（72.53 ±8.34）、（40.07 ±7.13） ng/L].IL-5 and ET and CGRP levels were significantly higher in CRS than control.Conclusion：It is found that concentrations of IL-5,ET and CGRP rised significantly in AR.IL-5,ET and CGRP may be involved in pathogenesis of AR and be related with the development of AR.