Does age worsen EEG slowing and attention deficits in obstructive sleep apnea syndrome? |
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| Authors: | Annie Mathieu Stéphanie Mazza Dominique Petit Anne Décary Jessica Massicotte-Marquez Jacques Malo Jacques Montplaisir |
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| Affiliation: | 1. Centre d’étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Coeur de Montréal, 5400 boul. Gouin Ouest, Montréal, Que., Canada H4J 1C5;2. Department of Medical Bioscience, Université de Montréal, Canada;3. Department of Psychiatry, Université de Montréal, Canada;4. Department of Psychology, Université de Montréal, Canada;5. Service de pneumologie, Hôpital du Sacré-Coeur de Montréal, Montreal, Que., Canada;1. 3rd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland;2. Department of Medical Education, Jagiellonian University Medical College, Krakow, Poland;1. School of Population and Global Health, The University of Melbourne, Melbourne, Australia;2. Department of Community Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka;3. The Institute for Breathing & Sleep, Heidelberg, Melbourne, Australia;4. Department of Lung and Sleep Medicine, Monash Health, Clayton, Australia;5. School of Clinical Sciences, Monash University, Clayton, Australia;1. ResMed Science Center, San Diego, CA, USA;2. Department of Medicine, University of British Columbia, Vancouver, BC, Canada;3. Centre for Sleep Science, School of Human Sciences, University of Western Australia, and Department of Pulmonary Physiology and Sleep Medicine, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Perth, WA, Australia;4. Center for Investigation and Research in Sleep (CIRS), University Hospital of Lausanne, Lausanne, Switzerland;5. Department of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China;6. National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, London, UK;7. Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA;8. Charité - Universitätsmedizin Berlin, Berlin, Germany;9. HP2 Laboratory, INSERM U1042, Univ. Grenoble Alpes, and EFCR laboratory, Grenoble Alpes University Hospital, Grenoble, France;10. Department of Population Health Sciences, University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA;11. All India Institute of Medical Sciences, New Delhi, India;12. Universidade Federal de Sao Paulo, Sao Paulo, Brazil;13. University of California San Diego, La Jolla, CA, USA;1. Department of Respiratory Medicine, Cork University Hospital, Cork, Ireland;1. School of Nursing, Indiana University, Indianapolis, IN 46202, United States;2. School of Engineering and Technology, Indiana University-Purdue University, Indianapolis, IN 46202, United States;3. Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, United States |
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| Abstract: | OBJECTIVE: The aim of this study was to determine whether EEG slowing is more pronounced in older than younger OSAS patients and to verify whether this cortical slowing is correlated to daytime performance, respiratory perturbation and sleep fragmentation. METHODS: Twelve young OSAS patients (mean age 38.2+/-2.0 y) and 13 older OSAS patients (mean age 62.2+/-1.9 y) along with 13 young controls (mean age 35.8+/-2.0 y) and 14 older controls (mean age 60.2+/-2.0 y) underwent a polysomnographic evaluation followed by a waking EEG recording. As a global index of cortical slowing, a ratio of slow-to-fast frequencies was calculated in all cortical regions. Daytime performance was assessed using the four choice reaction time test. RESULTS: Differences in waking EEG and in daytime performance were analyzed by ANOVAs with Group and Age as factors. Waking EEG did not yield a Group by Age interaction. OSAS patients had higher ratios across all regions than controls. Similarly, daytime performance revealed no Group by Age interaction. However, OSAS patients showed more lapses than controls and older subjects were slower than younger subjects. CONCLUSIONS: Our results indicate that age does not interact with OSAS to worsen the severity of cortical slowing, but age can add to the OSAS effect to worsen daytime performance deficits in OSAS patients. SIGNIFICANCE: The daytime performance deficits observed particularly in elderly OSAS patients warrant a careful clinical assessment of these patients to prevent accidents and injuries. |
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