高血压病患者动态脉压与左心室肥厚的关系

目的 :探讨高血压病患者左心室肥厚 (leftventricularhypertrophy ,LVH)与动态脉压和主动脉根部内径 (aorticrootdimension ,AOD)变化的关系。方法 :应用 2 4h动态血压监测和超声心动图检测 10 7例高血压病患者 ,以左室重量指数 (leftventricularmassindex ,LVMI)作为评价LVH的指标 ,将患者分为左心室肥厚组 (n =2 9)和无左心室肥厚组 (n =78)。结果 :2 4h平均脉压、白昼平均脉压、夜间平均脉压和主动脉根部内径在高血压左心室肥厚组和无左心室肥厚组之间差异均有显著性 (P <0 .0 5 ) ;多元逐步回归分析结果显示 :夜间平均脉压和AOD与LVMI的关系最密切 (P <0 .0 0 1)。结论 :主动脉根部内径和脉压 ,尤夜间平均脉压增大在LVH中起重要作用。

Ambulatory pulse pressure and left ventricular hypertrophy in patients with essential hypertension

Objective To evaluate the relationship between the left ventricular hypertrophy (LVH) and the ambulatory pulse pressure and aortic root dimension (AOD) in essential hypertensive patients. Methods We monitored the 24-hour ambulatory blood pressure and applied echocardiography in 107 essential hypertensive patients. Using the left ventricular mass index (LVMI) as an index in evaluating LVH,the patients were divided into 2 groups: 29 cases in the LVH group and 78 in the non-LVH group. Results The average levels of 24-hour pulse pressure,daytime pulse pressure,nighttime pulse pressure and AOD were significantly different between patients with LVH and without LVH (P<0.05). Multiple stepwise regression analysis showed that the changes in nighttime pulse pressure and AOD were closely related to LVMI (P<0.001). Conclusion The pulse pressure and AOD are important factors leading to LVH in patients with essential hypertension.