| 定量判断个体脑放射性分布异常的模型研究 |
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| 引用本文： | 赵雁,修雁,孙晓光,黄钢.定量判断个体脑放射性分布异常的模型研究[J].中国临床医学,2009,16(2). |
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| 作者姓名： | 赵雁 修雁 孙晓光 黄钢 |
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| 作者单位： | 1. 上海交通大学医学院附属仁济医院核医学科,上海,200127
2. 复旦大学附属中山医院核医学科,上海,200032 |
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| 基金项目： | 上海市教育委员会资助项目，上海市重点学科建设项目，上海市科委创新项目 |
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| 摘 要： | 目的:建立一种简单易行的用于诊断个体脑放射性分布异常的方法,并采用模型成像进行验证.方法:对Hoffman标准脑模型进行正电子发射断层扫描(PET)显像,得到15幅正常脑放射性分布图像,求得正常脑放射性分布图谱.利用Hoffman模型制作脑梗死模型和高放射性分布模型并进行PET成像,标准化后与正常脑放射性分布图谱进行比较,得到特定置信水平上的脑放射性分布差异图.结果:本试验中,脑图谱法对高放射性分布和低放射性分布病灶的检出率均为100%,对异常放射性分布有较高的灵敏度,并可以分别显示高于和低于正常值的差异程度.结论:该方法可以用于个体脑放射性分布的临床诊断,原理可靠,操作简单.
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| 关 键 词： | 正电子发射断层扫描 脑放射性分布 Hoffman模型 定量 |
Detecting Individual Brain Metabolism Quantitatively by Estimating Overall Average of Brain Phantoms |
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| ZHAO Yan,XIU Yan,SUN Xiaoguang,HUANG Gang.Detecting Individual Brain Metabolism Quantitatively by Estimating Overall Average of Brain Phantoms[J].Chinese Journal Of Clinical Medicine,2009,16(2). |
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| Authors: | ZHAO Yan XIU Yan SUN Xiaoguang HUANG Gang |
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| Institution: | ZHAO Yan1 XIU Yan2 SUN Xiaoguang1 HUANG Gang1 1. Department of Nuclear Medicine,Renji Hospital,Medical School of Shanghai Jiaotong University,Shanghai 200127,2. Department of Nuclear Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032 |
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| Abstract: | Objective:To establish a measurement on changes of individual cerebral metabolism featured with facility, stability and quantification. Methods:With 15 positron emission tomography (PET) images of Hoffman standard brain phantom, the normal cerebral metabolism atlas was generated and corrected by Bonferroni method for its high false positive. And PET images of high metabolism and low metabolism phantom were used to test the atlas. Results:The results of the method were consistent with true conditions in Hoff... |
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| Keywords: | Positron emission tomography Brain metabolism Hoffman phantom Quantification |
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