冠心病合并糖调节受损患者冠脉病变特点及临床特征

目的探讨冠心病合并糖调节受损患者的冠状动脉病变特点及临床特征。方法回顾分析我院2010-2011年冠状动脉造影阳性患者125例,分为糖代谢正常组（35例）、糖调节受损组（51例）、糖尿病组（39例）、所有患者均测定空腹血糖、餐后2h血糖、总胆固醇、甘油三脂、低密度脂蛋白、高密度脂蛋白、尿素氮、肌酐,观察其临床特征：年龄、性别、冠心病危险因素（包括高血压、高胆固醇血症、体重指数和吸烟）和冠状动脉病变情况有无差异。结果 3组患者在一般情况（年龄、性别、吸烟、高血压）等方面差异无统计学意义（P〉0.05）,而BMI、FBG、TG水平升高（P〈0.05）,HDL-C水平降低（P〈0.05）,有显著性差异;糖调节受损组及糖尿病组与糖代谢正常组比较,糖调节受损组及糖尿病组冠脉病变多为多支病变,有显著性差异（P〈0.05）,而糖调节受损组和糖尿病组间多支血管病变的患病率的差异无统计学意义（P均〉0.05）。结论糖调节受损时冠状动脉已发生严重病变,病变呈弥漫性,与糖尿病组相近,应用口服葡萄糖耐量试验及时发现糖代谢异常患者非常重要。

The angiographic characteristics and clinical characteristic in patients with the impaired glucose regulation(IGR)

Objective To study the angiographic characteristics and clinical characteristic in patients with the impaired glucose regulation(IGR).Methods A total of 125 cases with coronary heart disease were divided into the normal glucose tolerance group(NGT 35 cases),impaired glucose tolerance group(IGT 51 cases) and type 2diabetes mellitus group(T2DM 39 cases),according to oral glucose tolerance test;the fasting plasma glucose,two hour postprandial blood glucose after taking 75g oral glucose,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),BUN,creatinine(CR) were detected,meanwhile all cases were examined by coronary angiography.Results There were no significant differences in situations(including age,sex,smoking,hypertension)(P >0.05),but there were significant differences in higher fasting blood glucose,two hour postprandial blood glucose,BMI,TG(P <0.05) and lower HDL-C(P <0.05) glucose among three groups.The changes of coronary arteries of patients of Group IGT and Group T2DM were severer,more multivessel vascular lesions were found.There were no significant differences between three groups.There were no significant differences between Group Group IGT and Group T2DM.Conclusion IGR,similar to T2DM,can cause severe vessel lesions.OGTt test is important in the early diagnosis of patients with abnormal glucose metabolism.