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Peptide Hormone Production in Small Cell Lung Carcinomas with Particular Reference to Gastrin-Releasing Peptide |
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| Authors: | YAMAGUCHI, KEN ABE, KAORU ADACHI, ISAMU OTSUBO, KOTOMI NAGASAKI, KOICHI SUZUKI, MASAFUMI MARUNO, KANAME ASANUMA, FUMIKI TSUCHIHASHI, TAKAYUKI MIYAKE, YOSHIO YOSHINAGA, KEIGO MATSUBARA, HIDEKI IMANISHI, KOICHI KIMURA, SATOSHI KODAMA, TETSURO KAMEYA, TORU SHIMOSATO, YUKIO |
| Affiliation: | Endocrinology, National Cancer Center Research InstituteTokyo 4Endocrinology Divisions, National Cancer Center Research InstituteTokyo 1Department of Infectious Disease and Applied Immunology, InstItute of Medical Science, University of Tokyo Tokyo 2Department of Internal Medicine, National Matsudo Hospital, Matsudo Chiba 3Department of Pathology School of Medicine Kitasato University Sagamihara, Kanagawa |
| Abstract: | Tissues of 50 small cell lung carcinomas were examined for productionof 17 peptide hormones. Only when the concentration of a peptidedetected in the tumor was 10 pmol or more per g wet weight,was the peptide considered to be produced by the tumor. Thefrequency of production of at least one of these peptide hormoneswas 84%, and that of two or more hormones was 50%. These resultsindicate that peptide hormone production is a very common phenomenonin small cell lung carcinoma. Of the peptide hormones examined,gastrin-re leasing peptide is produced with the highest frequency,suggesting that this pep- tide could play an important rolein small cell lung carcinoma. |
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