| 2,6-二甲氧基-1,4-对苯醌的合成 |
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| 引用本文： | 杨健,郑虎. 2,6-二甲氧基-1,4-对苯醌的合成[J]. 华西药学杂志, 2006, 21(4): 352-353 |
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| 作者姓名： | 杨健 郑虎 |
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| 作者单位： | 四川大学华西药学院,四川,成都,610041;四川大学华西药学院,四川,成都,610041 |
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| 摘 要： | 目的合成2,6-二甲氧基-1,4-对苯醌。方法以香兰素为原料,经过溴化、甲氧基取代、氧化重排三步反应合成目标化合物。结果合成的目标化合物熔点、核磁谱与有关文献报道一致。结论所用工艺路线具有原料易得、操作简便、收率较高的特点,适用于2,6-二甲氧基-1,4-对苯醌原料的放大制备和生产。
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| 关 键 词： | 2 6-二甲氧基-1 4-对苯醌 合成 抗菌活性 香兰素 |
| 文章编号： | 1006-0103(2006)04-0352-02 |
| 收稿时间： | 2006-03-01 |
| 修稿时间： | 2006-03-01 |
Synthesis of 2,6-dimethoxy-1,4-benzoquinone |
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| YANG Jian,ZHENG Hu. Synthesis of 2,6-dimethoxy-1,4-benzoquinone[J]. West China Journal of Pharmaceutical Sciences, 2006, 21(4): 352-353 |
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| Authors: | YANG Jian ZHENG Hu |
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| Affiliation: | West China School of Pharmacy,Sichuan University, Chengdu 610041, China |
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| Abstract: | OBJECTIVE To synthesize 2,6-dimethoxy-1,4-benzoquinone.METHODS The target compound was synthesized from vanillin followed by bromination,methoxylation and rearrangement oxidation.RESULTS The title compound was obtained successfully in good yield.CONCLUSION The materials are available and the procedures are manipulated easily which makes the route practical and suitable to be scale-up. |
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| Keywords: | 2 6-Dimethoxy-1 4-benzoquinone Synthesis Antimicrobial activity Vanillin |
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