维生素E和C对肺癌介入化疗患者血浆LPO及红细胞SOD水平的影响

观察了20例使用和19例未使用维生素E(VE)和维生素C(VC)的肺癌患者在介入化学疗法(支气管动脉内药物注射)前后血浆LPD(过氧化脂质,lipid peroxide)和红细胞SOD(超氧化物歧化酶;superoxide dismutase)水平的变化,结果:1)未使用VE、VC的肺癌患者在介入化学疗法后血浆LPO水平明显上升(P<0.02)、红细胞SOD水平显著下降(P<0.01);2)使用VE、VC的患者在介入化学疗法后血浆LPO明显下降(P<0.05),红细胞SOD水平上升,但差异无显著性(P>0.05);3)血浆LPO水平和VC摄入量之间有明显负相关,r=-0.55(P<0.01),而和VE间无明显负相关,r=-0.02(P>0.05)。

EFFECT OF INSERTIONAL CHEMOTHERAPY WITH VITAMIN E AND VITAMIN C ON THE LEVELS OF PLASMA LPO AND RBC SOD IN PULMONARY CANCER PATIENTS

The change of plasma lipid peroxide (LPO) and RBC superoxide dismutase (SOD) in 39 cases of pulmonary cancer, amongst them 20 cases with and 19 cases without supplementation of vitamin E and vitamin C, before and after the insertional chemotherapy in the brachial artery were observed. The results showed. (l)The level of plasma LPO was elevated (P<0.02) and RBC SOD was reduced (P<0.01) if the pulmonary cancer patients were given insertional chemotherapy without vitamin E and vitamin C; (2) The level of plasma LPO was reduced (P<0.05) and RBC SOD tended to rise but not significantly different after the insertional chemotherapy with vitamin E and vitamin C; (3) The level of plasma LPO was negatively correlated with the intake of vitamin C(r = -0.55, p<0.01), but not with vitamin E (r= -0.22, P>05).