胃癌组织中MMP-9和TIMP-1的表达及其临床意义

背景：有关胃癌组织中基质金属蛋白酶（MMPs）和金属蛋白酶组织抑制剂（TIMPs）表达的研究不多且结果不一。目的：探讨胃癌组织中MMP-9和TIMP-1的表达及其临床意义。方法：收集临床病理资料完整的98例胃癌患者。应用免疫组化法检测组织中MMP-9和TIMP-1表达．并分析其与临床病理特征的关系以及各参数对胃癌患者预后的影响。结果：胃癌组织中MMP-9高表达与浸润深度、淋巴结转移和TNM分期显著相关（P〈0．01）。单因素分析显示胃癌患者预后与MMP-9高表达（P=0．014）、浸润深度（P〈0．001）、淋巴结转移（P〈0．0001）和TNM分期（P〈0．0001）相关。TIMP-1表达与胃癌患者临床病理特征和预后无关。结论：MMP-9高表达与胃癌的发生、进展有关，可作为胃癌患者预后指标之一。

Expressions and Clinical Significances of MMP-9 and TIMP-1 in Gastric Carcinoma

Background： Expressions of matrix metalloproteinases （MMPs） and tissue inhibitor of metalloproteinases （TIMPs） have not been well investigated in gastric carcinoma and the results reported are controversial. Aims： To investigate the expressions and clinical significances of MMP-9 and TIMP-1 in gastric carcinoma. Methods： Ninety-eight gastric carcinoma patients with complete clinical and pathologic data were collected. Immunohistochemical method was used to determine the expressions of MMP-9 and TIMP-1 in tissue, and their relationship with clinicopathotogical features and influences on prognosis of gastric carcinoma patients were analyzed. Results： Overexpression of MMP-9 was significantly correlated with depth of infiltration, lymph node metastasis and TNM staging （P〈0.01）. On univariate analysis, poor prognosis of patients with gastric carcinoma was correlated with overexpression of MMP-9 （P=-0.014）, depth of infiltration （P〈0.001）, lymph node metastasis （P〈0.0001） and TNM staging （P〈0.0001）. On the other hand, expression of TIMP-1 was not correlated with the clinicopathological features and prognosis of patients with gastric carcinoma. Conclusions： Overexpression of MMP-9 is correlated with the development and progression of gastric carcinoma, and can be served as a useful prognostic indicator in patients with gastric carcinoma.