甲苯胺蓝活体染色发现早期口腔粘膜癌变的评价

目的：为早期发现口腔粘膜斑纹类疾病的中的可癌变者，试用Ｏratest剂试，并对其敏感性和准确率进行评价，方法：采用英国ＺＩＬＡ公提供的Ｏratest试剂盒，对１９例口腔粘厂主 纹类疾病作常规染色，切取梁色后可疑病损区作组织病理检查，将病量珍断结果与染色结果对照比较，研究其相关性。结果：１９例中病理诊断有上皮异常增生８例，其中梁色阳性６例，阴性２例；无上皮异常增生７，其梁色阳性２例，阴性５例，原位癌４例，其染色阳性３例，阳性１例，观察发现上皮异常增生或原位癌中染色阳性者，其临床表现都有高度增残性角化现象，而无上皮异常增生的染色阳性者，其临床表现有糜料或溃疡，结论：Ｏratest不仅可以有效地提高粘膜癌变，而且对异产生的上皮细胞也有较高的亲和力，由于上皮异常增生是口腔粘膜由正常跨入癌变的第一步，因而对Ｏratest染色阳性者应引起高度警惕，其敏感性可达７５％，准确率达７４％，Ｏratest作一种筛选剂对于早期发现口腔粘膜的癌变或癌前病变切有临床意义。

The evaluation of toluidine blue stain in vivo for detecting oral musosa premalignant lesions

Objective This study was designed to detect the suspectable carcinogenesis in the patch or stria lesions of human oral mucosa at early stage.Oratest kits were applied for this purpose.The sensitivity and accuracy of this method was also evaluated. Methods 19 patch or stria lesions of human oral mucosa were tested by using Oratest kits which were kindly donated by ZILA Ltd.Com.Biopsies were also conducted in the suspected regions.The correlation analysis between staining and pathological examination was performed. Results 8 samples dysplasia which were revealed by 6 positive and 2 negative staining by using this Oratest examination.While the 7 samples with no dysplasia consisted of 2 positive and 5 negative staining.4 samples were confirmed to be cancer in situ.This included 3 positive and 1 negative staining. Conclusion It indicates that Oratest examination as an adjunct to clinical examination and biopsy,might detect malignant lesions and lesions of dysplasia.The sensitivity and accuracy reach the level of 75% and 74% respectively.It suggestes that Oratest examination be of sound clinical significance.