氟比洛芬酯在乳癌根治术中超前镇痛的疗效观察

目的:观察氟比洛芬酯在乳癌根治术中超前镇痛的有效性.方法:60例乳癌根治术患者随机分成A、B两组,每组各30例,均采用气管内全麻.A组为实验组,在气管插管完成后,手术开始前静注氟比洛芬酯100 mg.B组为对照组,于术毕时静注氟比洛芬酯100 mg.两组术后均未使用自控镇痛.采用疼痛视觉模拟评分法(VAS),评价患者拔管后10 min,回病房后4、8、12、24 h的疼痛感觉程度,并观察有关不良反应.结果:A纽术后24h的疼痛评分明显低于B组(P＜0.01).两组不良反应的发生率无显著差异.结论:在乳癌根治术中,氟比洛芬酯超前镇痛能有效减轻患者术后疼痛,不良反应小.

Clinical observation of flurbiprofen axetil on preemptive analgesia during radical operation of mastocarcinoma

Objective:To observe the preemptive analgesia effect of flurbiprofen axetil during radical operation of mastocarcinoma. Methods: Sixty patients undergoing radical operation of mastocarcinoma were randomly divided into two groups. Patients in both groups received general anesthsia. After tracheal intubation, the patients in group A (n=30) received intravenous of flurbiprofen axetil 100 mg before surgery, and those in group B (n=30) received intravenous of flurbiprofen axetil 100 mg after suturing the incision. Patient controlled intravenous analgesia ( PCIA) were not used in two groups. Postoperative analgesia efficacy was assessed by visual analogue scales(VAS) at 10min, 4, 8, 12 and 24 h after extubation, and adverse reactions of flurbiprofen axetil were also oberseved. Results: VAS were higher in the group B at 24 h after surgery compared with those in group A(P<0.01). The accidences of adverse reactions were similar between two groups. Conclusion: During radical operation of mastocarcinoma, flurbiprofen axetil can produce preemptive analgesia and reduce the adverse reaction.