3D left hyperschematia after right brain damage |
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| Authors: | Gilles Rode Patrice Revol Yves Rossetti Giuseppe Vallar |
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| Affiliation: | 1. Université de Lyon, Université Lyon 1, Inserm UMR-S 864, Bron, et Hospices Civils de Lyon, Service de Médecine Physique et Réadaptation, H?pital Henry Gabrielle , Saint-Genis-Laval, France;2. Université de Lyon, Université Lyon 1, ‘Mouvement et Handicap’ Plateforme IFNL-HCL, Institut Fédératif des Neurosciences de Lyon;3. Hospices Civils de Lyon , Lyon, France gilles.rode@chu-lyon.fr;5. Hospices Civils de Lyon , Lyon, France;6. Dipartimento di Psicologia , Università degli Studi di Milano-Bicocca , Milano, Italy;7. Laboratorio di Neuropsicologia , IRCCS Istituto Auxologico Italiano , Milan, Italy |
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| Abstract: | ABSTRACTDeep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson’s disease (PD). The STN may represent an important relay station not only in the motor but also the associative cortico-striato-thalamocortical pathway. Therefore, STN stimulation may alter cognitive functions, such as working memory (WM). We examined cortical effects of STN-DBS on WM in early PD patients using functional near-infrared spectroscopy. The effects of dopaminergic medication on WM were also examined. Lateral frontal activity during WM maintenance was greater when patients were taking dopaminergic medication. STN-DBS led to a trend-level worsening of WM performance, accompanied by increased lateral frontal activity during WM maintenance. These findings suggest that STN-DBS in PD might lead to functional modifications of the basal ganglia-thalamocortical pathway during WM maintenance. |
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| Keywords: | Hyperschematia Size distortion Left spatial neglect Left hemianopia Right brain damage |
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