Improvement of language functions in a chronic non-fluent post-stroke aphasic patient following bilateral sequential theta burst magnetic stimulation |
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Authors: | Jasmina Vuksanović Milan B Jelić Sladjan D Milanović Katarina Kačar Ljubica Konstantinović |
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Institution: | 1. Department of Neurophysiology, Institute for Medical Research, University of Belgrade, Beograd, Serbia;2. Department for Philosophy (Psychology), State University of Novi Pazar, Novi Pazar, Serbia;3. Radiology Department, Special Hospital for Cerebrovascular Diseases “Sveti Sava”, Belgrade, Serbia;4. Klinika za Rehabilitaciju “Dr Miroslav Zotovi?”, Belgrade, Serbia;5. Department of Rehabilitation, Faculty of Medicine, University of Belgrade, Belgrade, Serbia |
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Abstract: | In chronic non-fluent aphasia patients, inhibition of the intact right hemisphere (RH), by transcranial magnetic stimulation (TMS) or similar methods, can induce improvement in language functions. The supposed mechanism behind this improvement is a release of preserved left hemisphere (LH) language networks from RH transcallosal inhibition. Direct stimulation of the damaged LH can sometimes bring similar results too. Therefore, we developed a novel treatment approach that combined direct LH (Broca’s area (BA)) stimulation, by intermittent theta burst stimulation (TBS), with homologue RH area’s inhibition, by continuous TBS. We present the results of application of 15 daily sessions of the described treatment approach in a right-handed patient with chronic post-stroke non-fluent aphasia. The intervention appeared to improve several language functions, but most notably propositional speech, semantic fluency, short-term verbal memory, and verbal learning. Bilateral TBS modulation of activation of the language-related areas of both hemispheres seems to be a feasible and promising way to induce recovery in chronic aphasic patients. Due to potentially cumulative physiological effects of bilateral stimulation, the improvements may be even greater than following unilateral interventions. |
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Keywords: | aphasia transcranial magnetic stimulation rehabilitation interhemispheric interaction propositional speech verbal learning semantic fluency language stroke |
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