A case of semantic variant primary progressive aphasia with severe insular atrophy |
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| Authors: | T W Chow K A Links D L Masterman M F Mendez H V Vinters |
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| Institution: | 1. Baycrest Rotman Research Institute, Brain Health Complex , Toronto , ON , Canada;2. Department of Medicine, Division of Neurology and Department of Psychiatry, Division of Geriatric Psychiatry , University of Toronto , Toronto , ON , Canada tchow@rotman-baycrest.on.ca;4. Baycrest Rotman Research Institute, Brain Health Complex , Toronto , ON , Canada;5. Genentech , Los Angeles , CA , USA;6. Neurobehavior Unit, Greater Los Angeles VA Medical Center;7. UCLA Departments of Pathology and Laboratory Medicine, and Neurology, and the Mary Easton , Alzheimer Disease Research Center , Los Angeles , CA , USA |
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| Abstract: | Insular degeneration has been linked to symptoms of frontotemporal dementia (FTD). Presented in this case is a patient exhibiting semantic variant primary progressive aphasia, behavioral disturbance. Upon autopsy, he was found to have severe insular atrophy. In addition, selective serotonin reuptake inhibitors were ineffective in reducing symptoms of obsessive–compulsive behaviors or emotional blunting. This case suggests that Seeley et al.'s (2007 Seeley, W. W., Allman, J. M., Carlin, D. A. and et al. 2007. Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: Reciprocal networks and neuronal evolution. Alzheimer Disease & Associated Disorders, 21: S50–S57. Crossref], PubMed], Web of Science ®] , Google Scholar], Alzheimer Disease & Associated Disorders, 21, S50) hypothesis that von Economo neurons and fork cell-rich brain regions, particularly in the insula, are targeted in additional subtypes of FTD beyond the behavioral variant. |
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| Keywords: | Frontotemporal dementia MRI PET SPECT Insula |
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