Biomarker profiles and their relation to clinical variables in mild cognitive impairment |
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| Authors: | SNM Schoonenboom PJ Visser C Mulder J Lindeboom EJ Van Elk GJ Van Kamp |
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| Institution: | 1. Departments of Neurology , Alzheimer Centre niki.schoonenboom@vumc.nl;3. Departments of Neurology , Alzheimer Centre;4. Clinical Epidemiology, VU University Medical Centre , Amsterdam, the Netherlands;5. Department of Psychiatry , University of Maastricht , Maastricht, The Netherlands;6. Clinical Chemistry;7. Medical Psychology |
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| Abstract: | The aim of the study was to compare clinical variables between MCI patients at different risk for Alzheimer’s disease (AD) according to their biomarker profile. Fifty-four percent out of 39 MCI patients had a low Aβ42 and high tau in cerebrospinal fluid (CSF) (high-risk), 26% either a low CSF Aβ42 or high CSF tau (intermediate-risk) and 20% a normal CSF Aβ42 and tau (low-risk). Both high- and intermediate-risk subjects differed from the low-risk group in episodic memory, executive functions and the preclinical AD scale (PAS), which combines a set of clinical parameters. Subjects at high risk did not differ from subjects with an intermediate risk. Aβ42 levels correlated with the MTA and PAS scores, tau levels with episodic memory. These correlations suggest that the biomarkers are not independent when compared to the other AD markers. Longitudinal studies are necessary to interpret the correlations between biomarkers, imaging, and neuropsychological markers. |
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