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Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects |
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| Authors: | Ryota Hashimoto md phd Hiroko Noguchi ms Hiroaki Hori md Kazutaka Ohi md Yuka Yasuda md phd Masatoshi Takeda md phd and Hiroshi Kunugi md phd |
| Institution: | Osaka-Hamamatsu Joint Research Center for Child Mental Development,;Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka and;Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan |
| Abstract: | Aim: The dysbindin gene (dystrobrevin binding protein 1: DTNBP1 ) is a susceptibility gene for schizophrenia. Susceptibility genes for schizophrenia have been hypothesized to mediate liability for the disorder at least partly by influencing cognitive performance. This report investigated the relationship between cognitive function and the dysbindin gene. Methods: The possible association between a single nucleotide polymorphism (SNP) of DTNBP1 (rs2619539: P1655), which is a risk-independent SNP for schizophrenia in Japanese populations, and memory and IQ was investigated in 70 schizophrenia patients and 165 healthy volunteers in a Japanese population. Results: This SNP was associated with two memory scales, verbal memory and general memory, on the Wechsler Memory Scale–Revised (WMS-R), and three subcategories of the Wechsler Adult Intelligence Scale–Revised (WAIS-R), vocabulary, similarities and picture completion in healthy subjects. The SNP, however, did not influence either the indices of WMS-R, IQ or subcategories of WAIS-R in schizophrenia patients. Conclusion: A risk-independent SNP in DTNBP1 may have an impact on cognitive functions such as memory and IQ in healthy subjects. |
| Keywords: | DTNBP1 dysbindin IQ memory schizophrenia |