特发性炎性肌病合并间质性肺病患者血清表面活性蛋白A和D的水平及临床意义

目的通过对特发性炎性肌病(IIM)合并间质性肺病(ILD)患者的血清表面活性蛋白A(SP-A)和D(SP-D)的研究,探讨其与IIM合并ILD的相关性。方法采用双抗体夹心酶联免疫吸附试验检测SP-A和SP-D,比较单纯IIM组、IIM-ILD组、对照组血清样本SP-A和SP-D水平的差异。分析IIM-ILD组SP-A和SP-D与年龄、肌力、红细胞沉降率(ESR)、C反应蛋白(CRP)及肌酶之间的相关性。结果 1IIM-ILD组患者血清SP-A和SP-D水平高于单纯IIM组以及对照组(P<0.05)。单纯IIM组和健康对照组患者血清SP-A和SP-D水平比较差异无统计学意义(P>0.05)。血清SP-A、SP-D之间具有较高的正相关性。2IIM-ILD患者血清SP-A、SP-D水平与年龄、肌力、ESR、C反应蛋白及肌酶无相关性。结论 SP-A和SP-D与IIM合并ILD具有相关性,可作为IIM合并ILD的血清学标志,在早期诊断IIM合并ILD方面有一定价值。

Expression and significance of serum surfactant protein A and D in patients with idiopathic inflammatory ;myopathy complicated with interstitial lung diseases

Objective To investigate the correlation between idiopathic inflammatory myopathy （IIM） and inter-stitial lung disease （ILD） by assessment of the levels of surfactant protein A （SP-A） and D （SP-D）. Methods The lev-els of SP-A and SP-D in patients with IIM and those complicated with ILD （IIM-ILD） and healthy controls were as-sessed by using enzyme-linked immunosorbent assay. This allowed the comparison on the difference of SP-A and SP-D among the three groups and the correlation between SP-A and SP-D with age, muscular strength, erythrocyte sedimen-tation rate （ESR）, C-reactive protein （CRP） and creatine kinase. Results The levels of SP-A and SP-D in patients with IIM-ILD were markedly higher than those in IIM group and the healthy control group （both P〈0.05）. The differ-ence in SP-A and SP-D was not statistically significant between the latter two groups （P〉0.05）. There was a significant positive correlation between SP-A and SP-D. The levels of SP-A and SP-D in patients with IIM-ILD were not correlat-ed with age, muscular strength, ESR, CRP and creatine kinase. Conclusion SP-A and SP-D are correlated with IIM-ILD and may be valuable for the early diagnosis of IIM-ILD.