鼻咽癌组织中PD-1＋淋巴细胞数升高的意义

目的探讨鼻咽癌组织局部CD8＋和PD-1＋淋巴细胞在鼻咽癌发生发展中的作用。方法采用免疫组化方法检测64例鼻咽癌肿瘤组织和20例慢性鼻咽炎组织的CD8＋和PD-1＋淋巴细胞的分布情况。结果鼻咽癌肿瘤组织中CD8＋淋巴细胞百分比为（10.68±6.81）%,与慢性鼻咽炎组织的（28.5±9.33）%比较,差异有统计学意义（P〈0.05）;鼻咽癌组织中PD-1＋淋巴细胞为（10.4±5.95）%,与鼻咽炎组织的（6.8±3.21）%比较,差异有统计学意义（P〈0.05）。鼻咽癌组织中PD-1＋/CD8＋淋巴细胞比率为（1.24±0.91）,与鼻咽炎组织（0.28±0.2）比较,差异有统计学意义（P〈0.001）,但PD-1＋/CD8＋淋巴细胞比率升高与鼻咽癌临床分期无关。结论鼻咽癌组织中CD8＋淋巴细胞减少,PD-1＋淋巴细胞增加,提示PD-1可能参与鼻咽癌免疫逃逸,与鼻咽癌的发生有关。

Significance of PD-1 on tumor infiltrating lymphocytes in nasopharyngeal carcinoma

Objective To investigate the expression and significance of PD-1 in nasopharyngeal carcinoma （NPC）. Methods Immunohistochemistry method was used to detect CD8 and PD-1 expression of lymphocytes in 64 nasopharyngeal carcinomas and 20 chronic nasopharyngitis. Results Comparing with chronic nasopharyngitis, the lymphocytes with CD8 in NPC were decreased [（10.68±6.81）% vs （28.5±9.33）%,P〈0.05], while the lymphocytes with PD-1 were increased in NPC specimens [（6.8±3.21）% vs （10.4±5.95）%,P〈0.05]. The ratio of PD-1＋/CD8＋ lymphocytes was significantly up-regulated [（0.28±0.2） vs （1.24±0.91）, P0.001] in NPC,but it was not significantly correlated with clinical stage. Conclusion This result suggests that PD-1 may play a role in immune evasion of nasopharyngeal carcinoma.