D-二聚体在慢性肺源性心脏病患者中检测的临床意义

目的检测慢性肺源性心脏病急性加重期和临床缓解期患者血浆D-二聚体（D-dimer）含量的变化,分析其临床意义。方法慢性肺源性心脏病急性加重期和临床缓解期患者及正常对照组各30例,以ELISA法测定血浆D-dimer含量。结果慢性肺源性心脏病患者急性加重期和临床缓解期血浆D-dimer含量分别为（2.62±0.91）、（2.16±0.78）μg/L,均较正常对照者的（1.74±0.63）μg/L明显增高,差异有统计学意义（P〈0.05）;而急性加重期血浆D-dimer含量也明显高于缓解期（P〈0.05）。结论 D-dimer增高是慢性肺源性心脏病临床病理生理改变的结果,而且与疾病的严重程度有关。

Clinical study of the level of D-dimer in patients with chronic pulmonary heart disease

Objective To investigate the levels of D-dimer in the patients with pulmonary heart disease. Methods D-dimer in the plasma was measured in 30 cases with chronic pulmonary heart disease in the acute exacerbation, 30 cases with chronic pulmonary heart disease in the Clinical remission and in 30 healthy cases serving as controls. Results The levels of D-dimer in the patients with pulmonary heart disease in the acute exacerbation （2.62±0.91）μg/L] and the clinical remission （2.16±0.78）μg/L] were higher than that in the healthy control group （1.74±0.63）μg/L]. And the level of D-dimer in the patients with chronic pulmonary heart disease in the acute exacerbation（2.62±0.91）μg/L] was higher than that in the patients with clinical remission（2.16 ± 0.78）μg/L]. Conclusion D-dimer increased due to the change of clinical pathophysiology of chronic pulmonary heart disease and correlating with the severity of pulmonary heart disease.