口腔疣状癌与口腔鳞状细胞癌差异基因表达的对比分析

目的研究口腔疣状癌与口腔鳞癌组织基因的差异表达，探讨口腔疣状癌（oral Verrucous carcinoma，OVC）与口腔鳞癌（oral squamous cell carcinoma，OSCC）的基因学基础。方法应用cDNA芯片技术对4例OVC和4例OSCC组织mRNA检测，通过芯片杂交、生物信息学处理，找出两者间差异表达基因。结果BioStarH-40芯片发现差异表达基因593条，差异表达基因占15．2％，其中表达增强283条（显著增强59条），表达降低310条（显著降低98条）。结论OVC与OSCC基因表达比较，差异有统计学意义，这些差异可能在各自不同的生物学行为中起重要作用。

Gene expression profile changes in oral verrucous carcinoma and oral squamous cell carcinoma

OBJECTIVE: To determine the difference in the gene expression between human oral verrucous carcinoma (OVC) and oral squamous cell carcinoma (OSCC). METHODS: cDNA chip was used to detect the mRNA of cancer tissue from 4 OVC and 4 OSCC. After profile bloted and handled by bioinformation, the gene expression of these two kinds of lesions was examined. RESULTS: Using the BioStarH-40 profile, 593 different expression of genes was found. The rate of different genes was 15.2%, of which the exprssion of 283 genes increased (59 genes significantly increased) and 310 genes decreased (98 genes significantly decreased) in OVC tissue than that in OSCC. CONCLUSIONS: The gene expression of OVC and OSCC was different, which many contribute to the different biological behavior of these two kinds of lesions.