磁共振功能成像在高级别胶质瘤疗效监测的研究进展

高级别胶质瘤的治疗是复杂多变的。目前高级别胶质瘤的标准治疗方案是手术+放疗+口服化疗。持续的后期脑磁共振成像(magnetic resonance imaging,MRI)检查区分治疗反应与治疗效果可能具有困难,影响临床决策。各种先进的MRI技术(例如扩散加权成像、灌注加权成像、波谱分析、多参数成像)现在可以结合新的生理和生化参数,提供新的方法来帮助区分肿瘤进展,即假性进展和假性反应。本文总结了MR功能成像在监测高级别胶质瘤疗效方面的最新进展和挑战。

Progress of functional MR imaging on the monitoring of therapeutic effects of high-grade gliomas

The current management of high-grade gliomas is complicated and changeable. The standard treatment for HGGs is resection and followed by radiotherapy and oral chemotherapy at present. However, the continuous cranial magnetic resonance imaging (MRI) that differentiates treatment response from treatment effect can be challenging and affects clinical decision-making in later stages. A variety of advanced MRI techniques such as diffusion weighted imaging, perfusion weighted imaging, MR spectroscopy, and multiparametric imaging incorporating novel physiologic and biochemical parameters might provide new methods to help characterize tumor progression, pseudoprogression, and pseudo response. In this review, the latest progresses and challenges regarding MR functional imaging in the area of monitoring the efficacy of HGGs are summarized.