盐酸戊乙奎醚用于麻醉前给药的可行性观察

目的观察盐酸戊乙奎醚作为麻醉前抗胆碱药的可行性。方法20~50岁病人40例,随机分为盐酸戊乙奎醚组(A组),东莨菪碱组(B组),每组20例。病人进入手术室后肌肉注射盐酸戊乙奎醚0.01mg/kg(A组)或东莨菪碱0.3mg(B组),记录入室后10m in、注射后20m in和45m in三个时间点心率和血压,并与基础值对照,同时观察术前30m in、手术开始后60m in、术后10m in病人面色、口干程度及分泌物情况。结果A组肌肉注射后心率、血压有轻微变化,与基础值比较差异无统计学意义(P>0.05);B组心率明显增快,与基础值比较差异有统计学意义(P<0.05)。两组病人面红、口干程度差异无统计学意义(P>0.05),术中60m in和术后10m in拔管分泌物测量两组差异有统计学意义(P<0.05)。结论盐酸戊乙奎醚不增加心率并且有较强减少病人分泌物的作用。盐酸戊乙奎醚组作为麻醉前抗胆碱药应是可行的。

Clinical investigation of penehyclidine hydroclfloride used as a before - anesthesia prescription

Objective To investigate the feasibility of penehyclidine hydrochloride prescribed before anesthesia as a kind of anticholinergic drugs.Methods Forty patients aged 20~50 years were randomly divided into two groups:group A(penehyclidine hydrochloride) and group B(scopolamine) with 20 patients in each group.After entered the operation room,patients were injected penehyclidine hydrochloride 0.01 mg/kg(group A) or scopolamine 0.3 mg(group B).Recorded heart rate(HR) and blood pressure(BP) at 10min after entering operation room,20min and 45min after injection.Compared the result with base line value.Investigate the patient's complexion,degree of xerostomia and secretion at 30min before the operation,60min in the operation and 10min after the operation.Results HR and BP in group A fluctuated but the change had no statistical significance compared with group B(P>0.05).After intramuscular injection,HR increased significantly in group B than of group A(P<0.05).The degree of flame and xerostomia had no significant difference between the two groups(P>0.05).There was significant difference on secretion after operation between the two groups(P<(0.05)).Conclusion Penehyclidine hydrochloride has great effect on reducing the patient's HR.It will be a good choice as anticholinergic drug administrated before anesthisa.