速溶芦笋粉改善小鼠睡眠的研究

目的:观察速溶芦笋粉对小鼠睡眠的改善作用。方法:18～22 g健康雄性昆明种小鼠,随机分为5组,每组10只,皂苷含量为15%速溶芦笋粉低、中、高剂量组(85,170,510 mg·kg-1)、空白对照组、阳性对照组(酸枣仁皂苷360 mg·kg-1),连续ig 30 d后,进行戊巴比妥钠阈下剂量催眠试验、戊巴比妥钠睡眠潜伏期试验、延长戊巴比妥钠睡眠时间试验,观察对小鼠睡眠的影响。结果:速溶芦笋粉具有协同戊巴比妥钠阈下剂量催眠作用、可显著缩短戊巴比妥钠睡眠潜伏期、显著延长戊巴比妥钠睡眠时间。结论:速溶芦笋粉具有改善睡眠的作用。

Effect of Asparagus Instant Powder on Sleep Improvement in Mice

Objective: To study the effect of Asparagus instant powder (AIP) on sleep in mice. Method: Healthy KM male mice with the body weight of 18-22 g were divided into groups randomly. Then the mice were gavaged with AIP (containing 15% saponins) of low, middle and high doses (85,170,510 mg·kg^-1); control group (water)and positive control (Jujuboside 360 mg·kg^-1) respectively. The treatment was lasted for 30 days, the sleep-producing test was carried out by sub-threshold dose of sodium pentobarbital, and the incubation period test with sodium pentobarbital and the sleep extending test with sodium pentobarbital were also conducted. Result: AIP showed good sleep-producing action in sub-threshold dose test of sodium pentobarbital, could significantly shorten the incubation period induced by sodium pentobarbital, and could significantly prolong sleeping time induced by sodium pentobarbital. Conclusion: AIP can improve the sleep quality.