类风湿合并颈动脉硬化患者血清氧化应激状态与MMPs相关性分析

目的 探讨类风湿合并血清颈动脉硬化患者血清氧化应激状态与MMPs水平及临床意义.方法 选择缓解期类风湿患者92例,分为无颈动脉硬化组（A组）45例,合并颈动脉组（B组）47例,同时选择健康人群40例作为对照组（C组）.分别检测MMP-3、MMP-9、TIMP-1、MDA、SOD、GSH.结果 A组MMP-9、TIMP-1较C组均差异有统计学意义（P＜0.05）,B组MMP-3、MMP-9、TIMP-1较A组、C组差异有统计学意义（P＜0.05）.A组SOD、GSH较C组均存在下降（P＜0.05）,B组SOD、GSH较A组、C组79差异有统计学意义（P＜0.05）,MDA较A组有升高（P＜0.05）.SOD与MMP-9、TIMP-1有相关（P＜0.05）,与MMP-3未见相关性（P＞0.05）.GSH与MMP-3、MMP-9有负相关（P＜0.05）,与TIMP-1正相关（P＜0.05）.结论 稳定期类风湿合并颈动脉硬化患者MMPs与氧化应激的紊乱密切相关,共同促进颈动脉硬化的发生.

Correlation Analysis of Serum Oxidative Stress with MMPs in Rheumatoid Patients with Carotid Atherosclerosis

Objective The purpose of this study was to investigate the correlation of serum oxidative stress with MMPs in rheumatoid patients with carotid atherosclerosis.Methods Ninety-two cases of rheumatoid patients were divided into non-carotid atherosclerosis group （group A,45 cases） and carotid artery （group B,47 cases）,while 40 cases of healthy person were selected as the control group （group C）.MMP-3,MMP-9,TIMP-1,MDA,SOD and GSH were detected.Results There were significant differences in MMP-9 and TIMP-1 between groups A and C （P＜ 0.05）,and in MMP-3,MMP-9 and TIMP-1 between group B and the other two groups （P ＜ 0.05）.Compared with group C,SOD and GSH in group A have decreased significantly （P ＜0.05）.There were significant differences in SOD and GSH between group B and groups A and C,and MDA in group B increased significantly compared with group A （P ＜ 0.05）.SOD showed significant correlations with MMP-9 and TIMP-1 （P＜ 0.05）,while no correlation with MMP-3 （P ＞ 0.05）.There were negative correlations of GSH with MMP-3 and MMP-9 （P ＜ 0.05）,while was significant positive correlation with TIMP-1 （P ＜ 0.05）.Conclusion MMPs were closely related to the oxidative stress disorder in rheumatoid patients with carotid atherosclerosis,which promote the incidence of carotid artery atherosclerosis.