NSE、S100 在新生儿脑损伤中的联合应用

目的探讨NEC、S100在新生儿脑损伤中联合应用的应用价值。方法选取2010年2月-2012年2月该院出生的新生儿80例,其中40例新生儿为脑白质损伤,作为观察组,剩下的40例新生儿为健康新生儿,作为对照组,分别以两组新生儿出生后不同时间NES和S100蛋白值作为临床观察指标。结果观察组新生儿出生后24h、72h、120h的S100蛋白值均明显高于对照组新生儿：P〈0．05或P〈0．01;观察组新生儿出生后24h的NEC值明显高于对照组新生儿（P〈O．01）,两组新生儿出生后72h、120hNEC值差异无统计学意义（p〉0．05）。结论新生儿脑损伤患儿出生后120h的S100蛋白值明显高于正常新生儿,且24h内的NEC值也明显高于正常新生儿,其对新生儿脑损伤的临床诊断具有重要的意义,具有临床研究价值。

Combination Application of NSE and S100 in the Treatment of Neonatal Brain Injury

Objective To investigate the combined application value of NEC and S100 in the treatment of neonatal brain injury. Methods 80 cases of neonates born in our hospital from February, 2010 to February, 2012 were selected, including the observation group of 40 cases with cerebral white matter damage, and the control group of 40 cases of healthy newborns. The NES and S100 protein values in different time after the birth of two groups of neonates were used as the indicators of clinical observation, and the SPSS 13.0 software package was adopted for statistical analysis. Results The S100 protein values of the observation group 24h, 72h, 120h after the birth were significantly higher than those of the control group, }〉〈0.05 or P〈0.01. The value of NEC of the ob- servation group 24h after the birth was obviously higher than that of the control group, P〈0.01, but there were no statistically sig- nificant differences 72h, 120h after birth between the groups in the value of NEC, P〉0.05. Conclusion The S100 protein value of neonates with brain injury 120h after the birth was significantly higher than that of normal healthy newborns, and the value of NEC within 24h after the birth was significantly higher than that of normal healthy newborns, which have important significance in the clinical diagnosis of neonatal brain injury and clinical research value.