| 结肠清颗粒对溃疡性结肠炎模型大鼠血清IL-1、ICAM-1含量的影响 |
| |
| 引用本文： | 范立昌,薛玲,王静,高鲁霞.结肠清颗粒对溃疡性结肠炎模型大鼠血清IL-1、ICAM-1含量的影响[J].中国当代医药,2009,16(12):5-6. |
| |
| 作者姓名： | 范立昌 薛玲 王静 高鲁霞 |
| |
| 作者单位： | 1. 莒县人民医院药剂科,山东莒县,276500
2. 山东中医药大学,山东济南,250355 |
| |
| 摘 要： | 目的：探讨结肠清颗粒对溃疡性结肠炎模型大鼠血清白细胞介素1（IL-1）、细胞黏附因子（ICAM-1）的影响。方法：用家兔结肠加弗氏佐剂复制大鼠溃疡性结肠炎模型，检测模型大鼠血清IL-1、ICAM—1含量。结果：结肠清颗粒能显著增加溃疡性结肠炎模型大鼠血清IL-1及ICAM-1的含量；显著降低溃疡性结肠炎模型大鼠结肠的病理改变，对模型大鼠结肠有显著的修复作用。结论：结肠清颗粒治疗溃疡性结肠炎的作用可能与其升高血清IL-1及ICAM-1的含量，从而改善免疫功能。减轻炎症损伤有关。
|
| 关 键 词： | 结肠清颗粒 溃疡性结肠炎 IL-1 ICAM-1 |
Effects of Jiechangqing on IL-1 and ICAM-1 in the serum of Ulcerative Colitis Model Rats |
| |
| Authors: | FAN lichang XUE Ling WANG Jing GAO Luxia |
| |
| Institution: | FAN lichang, XUE Ling, WANG Jing, GAO Luxia (1.Juxian People＇s Hospital Pharmacy, Juxian 276500, China; 2.Shandong University of Traditional Chinese Medicine, Jinan 250355, China) |
| |
| Abstract: | Objective: To study the effects of Jiechangqing granule on the Ulcerative Colitis (UC) rats. Methods: To make the Ulcerative Colitis model rats by rabbit colon and Feud's adjuvant,and detected contents of IL-1 and ICAM-1 in the serum of the rats. Results: To compare with the model groups,the high-and mederate-dosage groups of Jiechangqing could up-regulated the contents of IL-1 and ICAM-1 and relieve the pathology changes significantly. Conclusion: Jiechangqing granule can up-regulated the levels of IL-1 and ICAM-1 contents in the serum of the rats ,which is the foundation to cure UC. |
| |
| Keywords: | IL-1 ICAM-1 |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
