| 520例慢性乙型肝炎HBeAg阴性与阳性患者临床和HBV-DNA比较分析 |
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| 引用本文： | 薛云平,邬小萍,温志立,杨铁一,袁小亮.520例慢性乙型肝炎HBeAg阴性与阳性患者临床和HBV-DNA比较分析[J].实用临床医学(江西),2007,8(8):25-27. |
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| 作者姓名： | 薛云平 邬小萍 温志立 杨铁一 袁小亮 |
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| 作者单位： | 南昌市第一医院感染科，南昌大学第一附属医院感染科，南昌市第一医院感染科，南昌市第一医院感染科，江西省胸科医院心内科 南昌330008，南昌330008，南昌330008，南昌330006 |
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| 摘 要： | 目的:了解HBeAg(-)慢性乙型肝炎(CHB)患者临床特点和血清HBV-DNA检测的意义。方法:对520例CHB患者的住院病历进行回顾性调查,分析HBeAg(-)和HBeAg( )CHB患者HBV-DNA定量组内和组间差异。结果:HBeAg(-)CHB 166例,占31.92%;HBeAg( )CHB 354例,占68.08%。HBeAg( )组HBV-DNA总体上高于HBeAg(-)组;不同病程HBeAg(-)CHB比例轻度组为12.8%,中度组为13.2%,重度组为19.2%,重型组为31.4%,肝硬化组为47.5%。结论:目前我国CHB病例以HBeAg( )者占多数,HBeAg( )组HBV-DNA总体上高于HBeAg(-)组,随着病程进展HBeAg(-)CHB比例上升。
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| 关 键 词： | 乙型肝炎 慢性 乙型肝炎病毒e抗原 乙型肝炎病毒 DNA |
| 文章编号： | 1009-8194（2007）08-0025-03 |
| 修稿时间： | 2007-07-09 |
A Comparison of Clinical and HBV-DNA of 520 Cases of HBeAg-negative and HBeAg-positive Chronic Hepatitis B |
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| XUE Yun-ping,WU Xiao-ping,WEN Zhi-li,YANG Tie-yi,YUAN Xiao-liang.A Comparison of Clinical and HBV-DNA of 520 Cases of HBeAg-negative and HBeAg-positive Chronic Hepatitis B[J].Practical Clinical Medicine,2007,8(8):25-27. |
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| Authors: | XUE Yun-ping WU Xiao-ping WEN Zhi-li YANG Tie-yi YUAN Xiao-liang |
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| Institution: | 1. Department of Infectious Daiasease , the First Hospital of Nanchang , Nanchang 330008, China ;2. Department of Infectious Diasease ,the First Affiliated Hospital of Nanchang University ; 3. Department of Cardiovasology , Jiang Xi Chest Hospital, Nanchang 330006, China |
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| Abstract: | Objective:To investigate the clinical characteristics and the implications of HBV DNA of HBeAg-negative and HBeAg-positive chronic hepatitis B(CHB).Methods: A total of 520 hospitalized CHB cases were analyzed retrospectively.The serum HBV DNA level was analyzed by their serum HBeAg status.Results: Among the 520 cases,166(31.92%) were HBeAg-negative and 354(68.08%) were HBeAg-positive.Compared with HBeAg-positive group,HBeAg-negative group had a lower serum HBV DNA levels.There were 13(12.8%),27(19.2%),27(13.2%),11(31.4%),and 19(47.5%) HBeAg-negative CHB cases in mild group(n=101),middle group(n=204),heavy group(n=140),severe group(n=35),and cirrhosis group(n=40) respectively.Conclusion: HBeAg-positive CHB is still the predominant form of CHB in Chinese patients.HBeAg-positive group had a higher serum HBV DNA levels than HBeAg-negative group.The rate of HBeAg-negative CHB/total CHB rises with the development of process. |
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| Keywords: | hepatitis B chronic hepatitis B e antigens HBV-DNA |
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