| 山茱萸中5-羟甲基糠醛的分离鉴定及生物活性研究 |
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| 引用本文： | 丁霞,王明艳,余宗亮,胡魏,蔡宝昌.山茱萸中5-羟甲基糠醛的分离鉴定及生物活性研究[J].中国中药杂志,2008,33(4):392-396. |
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| 作者姓名： | 丁霞 王明艳 余宗亮 胡魏 蔡宝昌 |
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| 作者单位： | 1. 南京农业大学,应化系,江苏,南京,210095
2. 南京医药大学,江苏,南京,210029 |
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| 摘 要： | 目的:探讨山茱萸炮制后补肝益肾作用增强的物质基础及5-羟甲基糠醛(5-HMF)的生物活性。方法:结合药理实验与化学研究筛选出活性部位,并从炮制品二氯甲烷活性部位中分离鉴定出主要单体成分,并进行体内和体外药理试验,研究其生物活性。结果:单体化学成分为5-羟甲基糠醛,它对小鼠CC l4肝损伤模型和血管内皮细胞具有保护作用,抗氧化作用是其保护作用的机制之一。结论:5-羟甲基糠醛是山茱萸炮制品中的活性成分,是补肝益肾作用的物质基础之一。
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| 关 键 词： | 山茱萸 5-羟甲基糠醛 分离鉴定 生物活性 |
| 文章编号： | 1001-5302（2008）04-0392-05 |
| 收稿时间： | 2006-04-10 |
Studies on separation,appraisal and the biological activity of 5HMF in Cornus officinalis |
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| DING Xia ;WANG Ming-yan ;YU Zong-liang ;HU Wei ;CAI Bao-chang.Studies on separation,appraisal and the biological activity of 5HMF in Cornus officinalis[J].China Journal of Chinese Materia Medica,2008,33(4):392-396. |
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| Authors: | DING Xia ;WANG Ming-yan ;YU Zong-liang ;HU Wei ;CAI Bao-chang |
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| Abstract: | Objective: To develop the mechanism of improving protection function of prepared Cornus officinalis for liver and kidney and the biological activity of 5-hydroxymethylfurfural(5-HMF).Method: Pharmacological and chemical studies were used to choose active part.A compound from active part was separated and appraised.To investigate his biological functions,pharmacological experiment was actualized.Result: A component was separated and identified.His is 5-HMF.5-HMF can protect human vein epidermal cell against H2O2 and glucose and inprove acute liver injury in mice.Conclusion: 5-HMF is the active component in prepared Cornus officinalis and substance basis for protecting liver and kidney. |
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| Keywords: | Cornus officinalis 5-hydroxymethylfurfural separation and appraisal biological activity |
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