| 碘对甲状腺冷热结节细胞生长的调节特点 |
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| 引用本文： | 覃又文,刘超,刘翠萍,段宇,武晓泓,狄福松,蒋须勤.碘对甲状腺冷热结节细胞生长的调节特点[J].江苏医药,2000,26(3):167-168. |
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| 作者姓名： | 覃又文 刘超 刘翠萍 段宇 武晓泓 狄福松 蒋须勤 |
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| 作者单位： | 南京医科大学第一附属医院内分泌科,210029 |
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| 摘 要： | 研究碘对以冷或热结节为表现的甲状腺腺瘤细胞生长的调节特征，探讨碘在甲状腺结节发病机理中的作用。方法手术切取甲状腺腺瘤及腺瘤旁正常组织，采用单层细胞培养技术和非同位素标记的细胞增殖分析法，检测不同浓度碘化钠经过不同作用时间对甲状腺细胞生长的影响。
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| 关 键 词： | 碘 甲状腺 生长 碘转运体 |
| 修稿时间： | 1999-09-26 |
The inhibitory effect of iodide on growth of cultured thyrocytes from thyroid adenomas |
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| QIN Youwen,LIU Chao,LIU Cuiping,et al..The inhibitory effect of iodide on growth of cultured thyrocytes from thyroid adenomas[J].Jiangsu Medical Journal,2000,26(3):167-168. |
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| Authors: | QIN Youwen LIU Chao LIU Cuiping |
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| Institution: | QIN Youwen,LIU Chao,LIU Cuiping,et
al.;
(Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical
University,Nanjing 210029) |
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| Abstract: | Objective To investigate the different response of functioning(hot nodules)and non functioning(cold nodules) thyroid adenomas to iodide.Methods Cell titer 96 Non radioactive Cell Proliferation Assay was used to study the growth of cultured thyrocytes from thyroid adenomas and paraadenomatous tissues in response to various concentration of sodium iodide(NaI).Results NaI inhibited the growth of thyroid cells from both normal and adenomatous tissues in a dose and time dependent manner.The inhibitory effect was greatest in functioning adenomas.Non functioning adenomatous thyroid cells had a lower response than paraadenomatous normal thyrocytes.Moreover,the responsiveness of thyroid cells to iodide on the same type of thyroid was quite different.Conclusion The inhibitory effect of iodide on thyroid growth depends on the iodide uptake by thyrocytes.The changes of expression of sodium/iodide symporter might play an important role in the pathogenesis of thyroid nodules. |
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| Keywords: | Iodide Thyroid Growth Sodium/Iodide symporter |
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