| 人体正常皮肤及瘢痕组织中CD3~ 表皮内T细胞的形态学研究 |
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| 引用本文： | 蔡哲,马海欢,赵茹,岳纪良,尹艳花. 人体正常皮肤及瘢痕组织中CD3~ 表皮内T细胞的形态学研究[J]. 中华烧伤杂志, 1999, 0(6) |
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| 作者姓名： | 蔡哲 马海欢 赵茹 岳纪良 尹艳花 |
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| 作者单位： | 中国医学科学院中国协和医科大学整形外科研究所 100041北京 |
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| 基金项目： | 本课题受国家自然基金资助(编号:39700144) |
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| 摘 要： | 目的通过对 CD3~ 表皮内 T 细胞在人体正常皮肤及瘢痕组织中的分布密度的研究,阐明表皮内 T 细咆对表皮细胞发育分化、分裂再生的影响。方法利用组织学和免疫组织化学法,观察表皮内 T 细胞在表皮组织中的分布。结果正常表皮组织中存在有少量 CD3~ 表皮内 T 细胞,增生性瘢痕组织中可见较正常组织数量多的 CD3~ 表皮内 T 细胞,表皮细胞增生活跃,萎缩性瘢痕组织中未发现有 CD3~ 表皮内 T 细胞存在,表皮细胞层平坦。结论正常皮肤组织和瘢痕组织中CD3~ 表皮内 T 细胞的分布情况不同,提示 CD3~ 表皮内 T 细胞可能与表皮细胞的发育分化、分裂再生有关,CD3~ 表皮内 T 细胞在表皮组织中的正常分布,对维持表皮组织的正常形态可能具有特殊意义。
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| 关 键 词： | 表皮内 T 细胞 瘢痕 |
Morphological study of CD3~ dendritic epidermal T cells in human skin and scar |
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| CAI Zhe MA Hal- huan ZHAO Ru,Plastic Surgery Institute,Chinese Academy of Medical Sciences,Beijing. Morphological study of CD3~ dendritic epidermal T cells in human skin and scar[J]. Chinese journal of burns, 1999, 0(6) |
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| Authors: | CAI Zhe MA Hal- huan ZHAO Ru Plastic Surgery Institute Chinese Academy of Medical Sciences Beijing |
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| Affiliation: | CAI Zhe MA Hal- huan ZHAO Ru,Plastic Surgery Institute,Chinese Academy of Medical Sciences,Beijing 100041 |
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| Abstract: | Objective To investigate the CD3/TCR - bearing T cell in the epidermis and explore the influence of the dendritic epidermal T cells on regeneration and differentiation of epidermal cells.Meth- otis The CD3/TCR-bearing T cells in epidermis of human skin and cicatrix were examined by means of histomorphology and immunohistochemistry.Results It was found that the density of CD3/TCR-bearing T cells in human skin and scar tissue had great dissimilarity.CD3~ dendritic epidermal T cells increased in hyperplastic scar.Such result was not observed in atrophic scar.Conclusion Our findings indicate CD3~ dendritic epidermal T cells regulate the generation and differentiation of epidermal cells.CD3~ dendritic epidermal T cells may play an important role in the maintenance of the morphology of epidermal tissue. |
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| Keywords: | Dendritic epidermal Tcell(DETC) Cicatrix |
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