Ki-67在侵袭性脑膜瘤的表达与意义

目的探讨Ki-67表达水平与脑膜瘤侵袭性的关系。方法回顾性分析68例脑膜瘤病例资料,根据肿瘤侵袭性与否,分为侵袭组（n=18）和非侵袭组（n=50）,测定Ki-67的表达水平,并进行统计学分析。结果男性病人中侵袭性脑膜瘤的发生率（41.7%）明显高于女性（18.2%）（P〈0.05）。不同病理等级,侵袭性脑膜瘤的发生率有明显差别（P〈0.05）。不同年龄段及病理类型,侵袭性脑膜瘤发生率无明显差别（P〉0.05）。脑膜瘤侵袭性或性别,与Ki-67表达水平无明显相关性（P〉0.05）。病理等级和Ki-67表达水平有明显相关性（P〈0.05）。结论 Ki-67表达水平主要与病理等级有关。在相同病理等级脑膜瘤中,Ki-67表达水平与脑膜瘤侵袭性无明显相关性。

Expression and its significance of Ki-67 in invasive meningioma

Objective To investigate the relationship between expression levels of Ki-67 and invasiveness of meningioma. Methods The clinical data of 68 patients with meningioma were analyzed retrospectively. According to the tumor invasion, the patients were divided into invasive group（n = 18） and non-invasive group（n = 50）. The level of Ki-67 was measured and analyzed statistically.Results The incidence of invasive meningiomas was significantly higher in male patients（41.7%） than women（18.2%, P 〈0.05）. In different pathological grades, the incidence of invasive meningiomas was obviously different（P〈 0.05）. Different ages and pathological subtypes had significantly different incidence of invasive meningiomas（P〉 0.05）. There was no statistically significant difference in relevance to the Ki-67 level between meningioma invasion and gender（P 〉0.05）, but the relevance between the pathological grade and Ki-67 level was statistically significant（P〈 0.05）. Conclusion Ki-67 level is related to mainly the pathological grade. In the meningioma with the same pathological grade, the level of Ki-67 is of no significant relevance to meningioma invasion.