Delayed episodic memory recall after one week is associated with executive functions and divided attention in pediatric epilepsy patients |
| |
| Affiliation: | 1. Department of Pediatric Neurology and Developmental Medicine, University Children''s Hospital Basel (UKBB), Basel, Switzerland;2. Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;3. Division of Neuropaediatrics, Development and Rehabilitation, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;4. Department of Psychosomatics and Psychiatry, University Children''s Hospital Zurich, Zurich, Switzerland;5. Division of Pediatric Neurology, Department of Pediatrics, Children’s Hospital Lucerne, Lucerne, Switzerland;6. Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland;1. Division of Child Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan;2. Division of Perinatology and Pediatrics, Faculty of Medicine, Tottori University, Yonago, Japan;1. Department of Pediatrics, Tokyo Women''s Medical University Yachiyo Medical Center, Chiba, Japan;2. Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan;3. Department of Pediatrics, Chibaken Saiseikai Narashino Hospital, Chiba, Japan;4. Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;5. Department of Pediatrics, National Rehabilitation Center for Children with Disabilities, Tokyo, Japan |
| |
| Abstract: | AimRecent studies suggest that although children with epilepsy may show normal learning and memory performance, accelerated long-term forgetting (ALF) may become evident over time. Our study examined associations between delayed episodic memory performance (recall 1-week after learning) and executive functions.MethodA consecutive sample of children with a diagnosis of idiopathic epilepsy with focal or generalized seizures, without morphologic or metabolic abnormalities (n = 20, mean age: 11.70 years) was compared to an IQ-matched healthy control group (n = 20, mean age: 11.55 years). We also assessed parents’ and children’s rating of forgetting in everyday life and explored its association with delayed episodic memory recall.ResultsSimilar to results from recent studies of pediatric patients with temporal lobe epilepsy or genetic generalized epilepsy, our pediatric epilepsy patients showed a significantly elevated recall loss over time, although verbal learning, immediate and 30-minute recall was comparable to the matched control group. Additionally, delayed memory recall in patients was moderately associated with their subjective rating of forgetting, as well as with executive functions (verbal fluency and switching) and divided attention.InterpretationWe assume that executive functions play a crucial role in deep memory encoding, facilitating stronger and more enduring memory traces. Given that approximately 20% of epilepsy patients – compared to a healthy reference sample – had a significantly reduced delayed recall and due to the clinical relevance of long-term memory, age-appropriate standard norms for free memory recall after 1-week are desirable. |
| |
| Keywords: | Children Epilepsy Accelerated long-term forgetting Executive functions Subjective memory rating |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
