Clinical features and influencing factors of curative effect in children with acute laryngitis and laryngeal obstruction |
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| Institution: | 1. Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, the University of Tokyo, Tokyo, Japan;2. Swallowing Center, the University of Tokyo Hospital, Tokyo, Japan;3. Faculty of Engineering Systems Innovation, the University of Tokyo, Tokyo, Japan;4. Department of Computational Diagnostic Radiology and Preventive Medicine, the University of Tokyo Hospital, Tokyo, Japan;5. AIC Yaesu Clinic, Tokyo, Japan;1. Department of Otolaryngology, The University of Tokyo, Tokyo, Japan;2. Department of Neurology, The University of Tokyo, Tokyo, Japan;1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan;2. Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan;1. Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, China;2. School of Computer Science and Cyber Engineering, Guangzhou University, Guangzhou, China |
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| Abstract: | ObjectiveWe aim to explore the clinical features and influencing factors of curative effect in children harboring acute laryngitis with laryngeal obstruction.MethodsThere involved 237 children with acute laryngitis and 80 healthy children who required physical examination in our hospital between January and September in 2021. The healthy children who required physical examination were allocated into the healthy/control group. The clinical data and laboratory indexes of each group were compared. We also analyzed the risk factors for curative effect of acute laryngitis with laryngeal obstruction among children using univariate/multivariate logistic regression.ResultsThe incidence of barking cough, sore throat, dryness, pruritus, dyspnea, diffuse congestion and swelling of laryngeal mucosa and vocal cord congestion or covered with vascular striation in degree III laryngeal obstruction group were significantly higher than other study groups, with degree II laryngeal obstruction group higher than degree I group, and degree I group higher than no laryngeal obstruction group (P<0.05). Moreover, the levels of CRP, TNF-α, IL-6, IL-8 and WBC in degree III laryngeal obstruction group were higher than other three study groups, with degree II higher than degree I laryngeal obstruction group and no obstruction group, and degree I higher than no laryngeal obstruction group (P<0.05). Multivariate logistic regression analysis showed that CRP, TNF-α, IL-6 and IL-8 were the risk factors affecting the curative effect of acute laryngitis with laryngeal obstruction in children, and the differences were statistically significant (P<0.05).ConclusionThe study revealed the incidence of barking cough, sore throat, dryness, pruritus, dyspnea, diffuse congestion and swelling of laryngeal mucosa vocal cord congestion or covered with vascular striation is highly associated with the severity of acute laryngitis with laryngeal obstruction in children. Additionally, higher levels of CRP, TNF-α, IL-6, IL-8 and WBC indicated serious condition of the disease among children. Hence the risk factors responsible for the efficacy of acute laryngitis in children are CRP, TNF-α, IL-6 and IL-8. |
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