FST estimates of 94 populations in China based on STR markers |
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| Affiliation: | 1. Forensic Science SA, GPO Box 2790, Adelaide, SA 5001, Australia;2. School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia;3. Institute of Environmental Science and Research Limited, Private Bag 92021, Auckland 1142, New Zealand;4. University of Auckland, Department of Statistics, Auckland, New Zealand;1. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, PR China;2. School of Clinical and Basic Medical Sciences, Shandong First Medical University& Shandong Academy of Medical Sciences, Jinan 250117, PR China;3. Jinan City Blood Center, Jinan 250001, PR China;4. Jinan Municipal Public Security Bureau, Jinan 250115, PR China;5. Queen Mary School, Nanchang University, Nanchang 330031, PR China;6. Shanxi Medical University, Taiyuan 030001, PR China;1. Center for Human Identification, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA;2. Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA;1. Forensic Science Programme, School of Chemical Sciences, The University of Auckland, Auckland, New Zealand;2. Forensic Research and Development Team, Institute of Environmental Science and Research Ltd, Auckland, New Zealand;1. MPS’s Key Laboratory of Forensic Genetics, National Engineering Laboratory for Crime Scene Evidence Investigation and Examination, Institute of Forensic Science, Ministry of Public Security (MPS), Beijing 100038, China;2. Faculty of Forensic Sciences, Shanxi Medical University, Taiyuan 030001, Shanxi, People’s Republic of China;3. Chinese Center For Disease Control And Prevention, State Key Laboratory of Infectious Disease Prevention and Control, Beijing 102206, China;4. Marine College, Shandong University, Weihai 264209, Shandong, China |
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| Abstract: | The proper assessment of DNA evidence in cases of personal identification is a recurring theme in forensics. It is common practice to evaluate the strength of DNA evidence using the likelihood ratio (LR). The accurate use of population allele frequencies is a crucial problem in LR calculation. Allele frequency differences among different populations could be estimated by the FST values. Thus, FST would also affect LR values by correcting the allele frequencies. In this study, Chinese population allele frequency data were selected from population reports published in Chinese and English journals. The population-specific FST values of each population, the overall FST values of each province, each region, and the whole country, and the locus-specific FST values of different loci were calculated. The LRs using different allele frequencies and different FST values were compared based on the combination of simulated genotypes. As a result, the FST values of 94 populations, 19 provinces, 7 regions, and the whole country were obtained. The LR was overestimated using allele frequencies of the combined population containing multiple populations rather than using allele frequencies of a population, and the LRs after FST correction were lower than those without correction. Conclusively, the correction in conjunction with corresponding FST values can make the LRs more accurate and reasonable. |
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| Keywords: | Forensic genetics Population genetics Short tandem repeat Likelihood ratio |
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