Primary diffuse large B-cell lymphoma of the Larynx |
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| Affiliation: | 1. Department of Otorhinolaryngology, Head and Neck Surgery, Juntendo University, Urayasu Hospital, 2-1-1 Tomioka, Urayasu-city, Chiba, Japan;2. Department of Hematology, Juntendo University, Urayasu Hospital, 2-1-1 Tomioka, Urayasu-city, Chiba, Japan;3. Department of Pathology, Juntendo University, Urayasu Hospital, 2-1-1 Tomioka, Urayasu-city, Chiba, Japan;4. Pathology Project for Molecular Targets, The Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto, Tokyo, Japan;1. Department of Otolaryngology-Head and Neck surgery, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Republic of Korea;2. Department of Otolaryngology-Head and Neck surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Republic of Korea;3. Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Korea;1. Department of Otolaryngology-Head and Neck Surgery, University of Tsukuba, Tsukuba, Japan;2. Department of Otolaryngology, National Hospital Organization Mito Medical Center, Mito, Japan;3. Department of Radiology, School of Medicine, International University of Health and Welfare, Narita, Japan;1. Department of Otolaryngology-HNS, Jeonbuk National University Medical School, Jeonju, Korea;2. Department of Physical Medicine and Rehabilitation, Jeonbuk National University Medical School, Jeonju, Korea;3. Department of Research Institute for Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk, 560-182, Korea |
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| Abstract: | The larynx is a rare site of extranodal non-Hodgkin lymphoma (NHL), accounting for less than 1% of all primary laryngeal neoplasms. We report a rare case of laryngeal diffuse large B-cell lymphoma (DLBCL) in an 85-year-old female patient, which was difficult to diagnose even after several biopsies from the primary laryngeal lesion, both under local and general anesthesia, and the diagnosis of DLBCL was obtained from the lymph node biopsy, which appeared in the proximity of the larynx 2 months after the first biopsy from the larynx. Since the diagnosis of laryngeal NHL is sometimes difficult when sufficient samples cannot be obtained, repeated biopsies may be required. Due to the small number of cases, there is no definite consensus regarding the best management of laryngeal NHL. Thus, a standard treatment option for DLBCL, such as 3 courses of R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine and prednisone) followed by Involved-field radiation therapy, or 6∼8 course of R-CHOP, are also applied for the treatment of laryngeal DLBCL. For this case, doxorubicin was not adopted and 8 courses of R-COP (rituximab + cyclophosphamide, vincristine and prednisone) at a decreased dose were chosen because of her age (85-year-old) and cardiac hypofunction. |
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