Intracellular antigens as targets for antibody based immunotherapy of malignant diseases
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| Authors: | Yangyang Wang Xinhui Wang Cristina R Ferrone Joseph H Schwab Soldano Ferrone |
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| Institution: | 1.Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States; 2.Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States |
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| Abstract: | This review discusses the potential use of intracellular tumor antigens as targets of antibody‐based immunotherapy for the treatment of solid tumors. In addition, it describes the characteristics of the intracellular tumor antigens targeted with antibodies which have been described in the literature and have been identified in the authors'' laboratory. Finally, the mechanism underlying the trafficking of the intracellular tumor antigens to the plasma membrane of tumor cells are reviewed. |
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| Keywords: | Intracellular tumor antigen PRL-3 Hsp70 Grp78 Grp94 Monoclonal antibodies |
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