Neurotransmitter effects on in vitro prolactin and growth hormone release from fowl pituitary glands: dopamine and noradrenaline |
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| Authors: | T R Hall S Harvey A Chadwick |
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| Affiliation: | 1. Faculty of Pharmacy, Drug Research Program, University of Helsinki, P.O.Box 56 00014, Finland;2. School of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland;3. Helsinki Institute for Sustainability Science, University of Helsinki, P.O. Box 4 00014, Finland;1. Canadian Medication Appropriateness and Deprescribing Network, Montreal, Université de Montréal, QC, Canada;2. School of Population and Public Health, University of British Columbia, Vancouver BC, Canada;3. Canadian Medication Appropriateness and Deprescribing Network, Université de Montréal, Montreal, QC, Canada;4. Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada;5. Alberta Health Services, Edmonton, AB, Canada;6. Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;7. Faculties of Pharmacy and Medicine, Université de Montréal, Montreal, QC, Canada;8. Michel Saucier Endowed Chair in Pharmacy, Health & Aging, Université de Montréal, Montreal, QC, Canada;9. Faculté de Pharmacie, Université de Montréal, Montreal, QC, Canada;10. Centre de Recherche de l''Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada;11. Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia |
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| Abstract: | Pituitary glands and hypothalami from broiler fowl heads were incubated alone or together with dopamine, noradrenaline or monoaminergic drugs (apomorphine, pimozide, phentolamine, isoproterenol and propranolol). The basal release of both prolactin and growth hormone was not affected by any of these amines or aminergic drugs. The co-incubation of pituitary glands with whole hypothalami consistently stimulated prolactin and growth hormone secretion. Apomorphine inhibited hypothalamus-induced prolactin and growth hormone release and the response was blocked by pimozide. Noradrenaline markedly stimulated hypothalamus-induced prolactin release, an effect antagonised by phentolamine. Thyrotrophin-releasing hormone (TRH) stimulated the release of prolactin and this stimulation was reversed, in a dose-related manner, by dopamine. TRH also increased the release of growth hormone, in the presence or absence of dopamine. These results demonstrate inhibitory dopaminergic effects on prolactin and growth hormone secretion and stimulatory noradrenergic effects on prolactin release. These aminergic effects may be mediated at pituitary and/or hypothalamic sites. |
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