In vitro activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer's disease |
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Authors: | Conforti Filomena Statti Giancarlo Antonio Tundis Rosa Loizzo Monica Rosa Menichini Francesco |
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Affiliation: | Department of Pharmaceutical Sciences, University of Calabria, Rende (CS), Italy. filomena.conforti@unical.it |
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Abstract: | The present study showed for the first time the in vitro properties (antioxidant, hypoglycaemic and anticholinesterase) of Citrus medica L. cv. Diamante which belongs to the Rutaceae family. The n-hexane extract of Diamante citron peel is characterized by the presence of monoterpenes and sesquiterpenes. The most abundant constituents were two monoterpenes: limonene and gamma-terpinene. The extract showed significant antioxidant activity that was carried out using different assays (DPPH test, beta-carotene bleaching test and bovine brain peroxidation assay). Oxidative damage, caused by the action of free radicals, may initiate and promote the progression of a number of chronic diseases, including diabetes and Alzheimer's disease. Diamante citron peel extract showed hypoglycaemic activity and an anticholinesterase effect. |
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Keywords: | Citrus medica L. cv. Diamante Rutaceae antioxidant and hypoglycaemic activities Alzheimer's disease |
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