| 单磷酸阿糖腺苷的合成 |
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| 引用本文： | 周莉红,项光亚,张汉萍,余汉华. 单磷酸阿糖腺苷的合成[J]. 中国药学杂志, 2006, 41(12): 954-955 |
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| 作者姓名： | 周莉红 项光亚 张汉萍 余汉华 |
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| 作者单位： | 1. 华中科技大学同济医学院药学院,武汉,430030
2. 武汉钢铁集团公司第二职工医院,武汉,430085 |
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| 摘 要： | 目的改进单磷酸阿糖腺苷的合成工艺。方法直接以阿糖腺苷为原料,对其进行磷酸化,经过精制纯化,得到单磷酸阿糖腺苷。结果单磷酸阿糖腺苷经紫外、核磁、质谱等证实。结论本法原料易得,操作简单,总收率高,是理想的工业化生产路线。
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| 关 键 词： | 单磷酸阿糖腺苷 抗病毒 合成 结构鉴定 |
| 文章编号： | 1001-2494（2006）12-0954-02 |
| 收稿时间： | 2006-02-23 |
| 修稿时间： | 2006-02-23 |
Synthesis of Vidarabine Monophosphate |
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| ZHOU Li-hong,XIANG Guang-ya,ZHANG Han-ping,YU Han-hua. Synthesis of Vidarabine Monophosphate[J]. Chinese Pharmaceutical Journal, 2006, 41(12): 954-955 |
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| Authors: | ZHOU Li-hong XIANG Guang-ya ZHANG Han-ping YU Han-hua |
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| Affiliation: | 1. Pharmacy School of Tonal Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;2. Second Affiliated Hospital of Wuhan Steel Group, Wuhan 430085, China |
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| Abstract: | OBJECTIVE To improve the synthesis methods of vidarabine monophosphate.METHODS Vidarabine monophosphate was synthesized by vidarabine phosphorylation directly in the present of pyridine and acetonitrile.The pure products were obtained by crystallization.RESULTS The structure of vidarabine monophosphate was confirmed by UV,NMR and MS analysis.CONCLUSION This method is suitable for industrialization,with high yield the materials are easily obtained with high yield. |
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| Keywords: | vidarabine monphosphate anti-virus synthesis structure identification |
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