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Effects of Xenon Anesthesia on Cerebral Blood Flow in Humans: A Positron Emission Tomography Study |
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| Authors: | Laitio, Ruut M. M.D. Kaisti, Kaike K. M.D.&#x L angsj , Jaakko W. M.D.&#x Aalto, Sargo M.Sc. Salmi, Elina M.D.&#x Maksimow, Anu M.D.# Aantaa, Riku M.D. Oikonen, Vesa M.Sc.&#x &#x Sipil , Hannu M.Sc.&#x &#x Parkkola, Riitta M.D. Scheinin, Harry M.D.&#x &#x |
| Affiliation: | Laitio, Ruut M. M.D.*; Kaisti, Kaike K. M.D.†; Låangsjö, Jaakko W. M.D.‡; Aalto, Sargo M.Sc.§; Salmi, Elina M.D.∥; Maksimow, Anu M.D.#; Aantaa, Riku M.D.**; Oikonen, Vesa M.Sc.††; Sipilä, Hannu M.Sc.‡‡; Parkkola, Riitta M.D.§§; Scheinin, Harry M.D.∥∥ |
| Abstract: | Background: Animal studies have demonstrated a strong neuroprotective property of xenon. Its usefulness in patients with cerebral pathology could be compromised by deleterious effects on regional cerebral blood flow (rCBF). Methods: 15O-labeled water was used to determine rCBF in nine healthy male subjects at baseline and during 1 minimum alveolar concentration (MAC) of xenon (63%). Anesthesia was based solely on xenon. Absolute changes in rCBF were quantified using region-of-interest analysis and voxel-based analysis. Results: Mean arterial blood pressure and arterial partial pressure for carbon dioxide remained unchanged. The mean (+/- SD) xenon concentration during anesthesia was 65.2 +/- 2.3%. Xenon anesthesia decreased absolute rCBF by 34.7 +/- 9.8% in the cerebellum (P < 0.001), by 22.8 +/- 10.4% in the thalamus (P = 0.001), and by 16.2 +/- 6.2% in the parietal cortex (P < 0.001). On average, xenon anesthesia decreased absolute rCBF by 11.2 +/- 8.6% in the gray matter (P = 0.008). A 22.1 +/- 13.6% increase in rCBF was detected in the white matter (P = 0.001). Whole-brain voxel-based analysis revealed widespread cortical reductions and increases in rCBF in the precentral and postcentral gyri. |
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