| 复方沙棘2号颗粒对大鼠局灶性脑缺血再灌注损伤的保护作用及机理探讨 |
| |
| 引用本文： | 程体娟,魏舒畅,张文斌,马建秀.复方沙棘2号颗粒对大鼠局灶性脑缺血再灌注损伤的保护作用及机理探讨[J].中国临床药理学与治疗学,2003,8(3):289-291. |
| |
| 作者姓名： | 程体娟 魏舒畅 张文斌 马建秀 |
| |
| 作者单位： | 1. 兰州医学院药理教研室,兰州730000,甘肃
2. 西北民族学院药理教研室,兰州730000,甘肃 |
| |
| 摘 要： | 目的：研究复方沙棘2号颗粒对大鼠局灶性脑缺血再灌注损伤的保护作用及作用机理。方法：线栓法制作局灶性脑缺血再灌注模型。检测脑梗死体积比，血清MDA含量，血清SOD和GSH－Px活性，并观察行为学改变。结果：大鼠脑缺血再罐注后，血清MDA含量和脑梗死体积比显增加，SOD和GSH—Pk活力明显下降。复方沙棘2号可有效地防止上述改变。结论：复方沙辣2号颗粒对脑缺血再灌注损伤有显保护作用。这种保护作用可能与提高脑组织抗脂质过氧化能力有关。
|
| 关 键 词： | 复方沙棘2号颗粒 局灶性脑缺血 再灌注损伤 脑梗死体积比 抗脂质过氧化能力 脑组织 |
| 文章编号： | 1009-2501(2003)03-0289-03 |
| 修稿时间： | 2002年11月11 |
Protection and mechanism of compound Hippophae rhamnoids L. granule 2 on focal cerebral ischemia-reperfusion in rats |
| |
| CHENG Ti-Juan,WEI Shu-Chang,ZHANG Weng-Bin,MA Jian-Xiu.Protection and mechanism of compound Hippophae rhamnoids L. granule 2 on focal cerebral ischemia-reperfusion in rats[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2003,8(3):289-291. |
| |
| Authors: | CHENG Ti-Juan WEI Shu-Chang ZHANG Weng-Bin MA Jian-Xiu |
| |
| Institution: | CHENG Ti-Juan,WEI Shu-Chang,ZHANG Weng-Bin,MA Jian-Xiu 1Department of Pharmacology,Lanzhou Medical College,Lanzhou 730000,Gansu, 1 Department of Pharmacology,Northwest National Col lege,Lanzhou 730000,Gansu |
| |
| Abstract: | AIM: To study the protection and mechanism of compound Hippophae rhamnoides L. granule 2 (CHRG2 ) on focal cerebral ischemia -reperfusion in rats. METHODS: Focal cerebral ischemia-reperfu sion model was made with suture-occluded method. The volume of cerebral infarct ion, the level of MDA in serum, the activities of SOD and GSH-Px in serum were measured. The behavior obstacles of rats were observed. RESULTS: After cerebral ischemia-reperfusion, the content of MDA in serum and the volum e of cerebral infarction increased significantly, the activities of SOD, and GSH -Px decreased significantly. CHRG2 could effectively prevent these changes. CONCLUSION: CHRG2 shows the protection against ischemia-reperfusio n injury, and the effect may be related to raising anti-peroxidation of the bra in tissue. |
| |
| Keywords: | pharmacology Hippophae rhamnoide s L cerebral ischemia-reperfusion injury SOD MDA GSH-Px |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
