不同促排卵方案在多囊卵巢综合征患者中应用对比研究

目的研究不同促排卵方案治疗多囊卵巢综合征的临床效果。方法选取120例多囊卵巢综合征患者,随机分为两组,各60例,对照组给予GnRH激动剂长方案治疗,观察组给予GnRH拮抗剂治疗,对比两组患者临床疗效。结果观察组患者Gn剂量、HCG日LH水平、E2水平以及周期取消率明显低于对照组,差异有统计学意义（P〈0.05）;观察组在获卵数、MII卵泡数、临床妊娠率、胚胎种植率、流产率及OHSS发生率等情况与对照组相比差异无统计学意义（P〉0.05）。结论采用GnRH-A方案进行促排卵治疗多囊卵巢综合征疗效显著,有效减少Gn用量,降低周期取消率及OHSS发生率。

Comparative study on the application of different methods of promoting ovulation in polycystic ovary syndrome patients

Objective To study the clinical effect of different methods of promoting ovulation in patients with polycystic ovarian syndrome. Methods 120 cases of polycystic ovary syndrome patients were randomly divided into two groups, each of 60 cases. The control group was given GnRH agonist treatment,the observation group was given GnRH antagonist treatment, the clinical efficacy were compared between two groups. Results In the observation group, Gn,HCG, LH, dose level and E2 level cycle cancellation rate was significantly lower than that of the control group, the difference was significant（P〈0.05）; in the observation group, the number of oocytes, the number of follicles in MII, clinical pregnancy rate, implantation rate, abortion rate and OHSS rate were compared with the control group no significant difference significance（P〉0.05）. Conclusion The GnRH-A scheme is the promoting effect of ovulation in polycystic ovary syndrome significantly, effectively reduce the amount of Gn, reduce the incidence rate of OHSS and cycle cancellation, is worth the clinical promotion.