血浆同型半胱氨酸水平变化在心肌梗死患者中的临床意义

目的：探讨心肌梗死患者血浆同型半胱氨酸水平变化及临床意义。方法选取2013年1月～2014年1月收治的心肌梗死患者55例作为观察组，选取同期健康体检者60例作为对照组。观察比较心肌梗死患者及健康体检者的血浆同型半胱氨酸（Hcy）、叶酸（Fol）、维生素 B12（VitB12）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。结果观察组患者的VitB12、Fol明显低于对照组，Hcy水平高于对照组，差异均有统计学意义（P均＜0.05）。观察组患者的TC、TG和LDL-C与对照组比较，差异均具统计学意义（P均＜0.05）；而HDL-C低于正常对照组，差异具统计学意义（P＜0.05）。血浆 Hcy水平与 TC、TG、LDL-C呈正相关，而血浆Hcy水平与HDL-C呈负相关。多因素logistic回归分析，结果表明血浆同型半胱氨酸是心肌梗死的独立致病因素。结论 Hcy作为心肌梗死的独立致病因素。Fol、VitB12、TC、TG、HDL-C和LDL-C同血浆Hcy有一定的相关性。

Clinical significance of change on plasma homocysteine of patients with myocardial infarction

Objective To discuss clinical significance of change on plasma homocysteine of patients with myocardial infarction.Methods55 patients with myocardial infarction of our hospital were selected as observation group, 60 healthy controls were selected as control group at the same time. Hcy,Fol,VitB12, TC,TG,HDL-Cand LDL-C of observation group and control group were observed and compared.Results VitB12, Fol of observation group were lower than that of control group, and Hcy was higher than that of control group（P〈0.05）.There were significant differences on TC,TG,LDL-C between observation group and control group（P〈0.05）,and HDL-C was lower, there were significant difference（P〈0.05）. The results of multivariate logistic regression analysis showed that the plasma homocysteine was the independent risk factor for myocardial infarction.Conclusion Homocysteine is the independent risk factors to myocardial infarction. There were some correlations between Fol,VitB12,TC,TG,HDL-C,LDL-C and Hcy.