Die Rolle der Strahlentherapie bei seltenen extranodalen Non-Hodgkin-Lymphomen

Extranodal non-Hodgkin lymphoma (NHL) accounts for approximately 30% of NHLs. Extranodal NHLs are mainly located in the skin (mainly T-cell NHL), stomach, small intestines, tonsils and central nervous system (CNS mainly B-cell lymphoma). Uncommon sites represent the orbit, salivary glands, nasal cavity, paranasal sinuses, thyroid gland, lungs, bladder, breast, female genital tract, testes, bone and extradural space. Stage, localization and histology are crucial for the decision of treatment modality. As, in contrast to nodal NHL, extranodal NHLs are more frequently diagnosed in stages I/II, radiotherapy (RT) plays a significant role in the treatment of extranodal NHLs. In general, in patients with low grade NHL involved-field radiotherapy (IF-RT) alone with 30?C40?Gy is recommended. Excellent local control is achieved by IF-RT resulting in high disease-free and overall survival rates. In cases of high grade lymphoma, induction chemotherapy is followed by consolidating IF-RT (36?C40?Gy). The localization and histology are predictors for local control, disease-free and overall survival.