习惯性流产的病毒病因探讨

目的用多种技术方法研究探讨柯萨奇B组病毒（CBV）与习惯性流产的病毒病因。方法采用ELISA、RT-PCR和病毒分离对86例习惯性流产和40例人工流产妇女进行了CBV．WM抗体、病毒RNA和病毒粒子检测。结果检测结果表明习惯性流产和人工流产两组妇女柯萨奇B组病毒IgM阳性率分别为87．2％和35．0％，血淋巴细胞CBVRNA阳性率则为53．5％N17．5％；而胎盘组织中病毒RNA阳性率各为59．3％N17．5％，胎盘组织中病毒分离阳性率在两组妇女各为41．9％和6．9％。其各项指标经χ^2检验，两组均有显著性差异（P〈0．01。结论柯萨奇B组病毒可能是习惯性流产的发生因素之一。

Investigation of viral pathogens contributing to habitual abortion

Objective To investigate the association of Coxsackie B virus (CBV) with habitual abortion. Methods CBV IgM antibody, viral RNA and virions were detected in 86 women with habitual abortion and 40 with induced abortion by means of enzyme-linked immunosorbent assay (ELISA), RT-PCR and virus isolation, respectively. Results The positivity rate of CBV IgM were 87.2% and 35% in the two groups, respectively, and the detection rate of the viral RNA was 53.5% and 17.5% in blood lymphocytes, and 59.3% and 17.5% in the placentas. The virions were found in the placentas in 41.9% and 6.9% of the women, respectively. The positiivty rates of CBV IgM, viral DNA and virions showed significant difference between the two groups (P<0. 01). Conclusion CBV might be one of the causes responsible for habitual abortion.