Associations of serum sclerostin with bone mineral density,markers of bone metabolism and thalassaemia characteristics in adult patients with transfusion-dependent beta-thalassaemia |
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| Authors: | Katya Sapunarova Vesselina Goranova-Marinova Pencho Georgiev Tanya Deneva Silvia Tsvetkova Zhanet Grudeva-Popova |
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| Affiliation: | 1. First Department of Internal Medicine, Department of Hematology, Medical University, Plovdiv, Bulgaria;2. Clinic of Clinical Hematology, University Hospital “Sv. Georgi”, Plovdiv, Bulgaria;3. kasapunarova@yahoo.com;5. Department of Clinical Laboratory, University Hospital “Sv. Georgi”, Plovdiv, Bulgaria;6. Department of Imaging Diagnostics, Medical University, Plovdiv, Bulgaria;7. Clinic of Clinical Hematology, University Hospital “Sv. Georgi”, Plovdiv, Bulgaria;8. Department of Medical Oncology, University Hospital “Sv. Georgi”, Plovdiv, Bulgaria |
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| Abstract: | AbstractAim of the study: To assess serum sclerostin in transfusion-dependent beta-thalassaemia patients versus healthy controls and to examine its associations with bone mineral density, bone metabolism markers and beta thalassaemia alterations.Material and methods: Sixty-two transfusion-dependent beta-thalassaemia (TDßT) patients and 30 healthy controls were evaluated for serum sclerostin, osteocalcin, beta-cross laps, osteoprotegerin and serum level of receptor activator of nuclear factor kappa-Β ligand (sRANKL). Bone mineral density was measured at the lumbar spine and femoral neck. Thalassaemia characteristics were collected from the patients’ medical records.Results: A significantly higher sclerostin level (median 565.50?pmol/L) was observed in the transfusion-dependent beta-thalassaemia patients vs. the healthy controls (median 48.65?pmol/L, p?Conclusion: Sclerostin may play a role in the bone pathophysiology of beta-thalassaemia patients and could serve as a marker of severe osteoporosis.- KEY MЕSSAGES
Serum sclerostin is more than 10-fold higher in adult patients with transfusion-dependent beta-thalassaemia compared to healthy controls. Serum sclerostin is negatively associated with bone mineral density and the bone synthesis markers and positively with the bone resorption indices. Serum sclerostin is significantly associated with pre-transfusion haemoglobin, liver iron concentration, splenectomy status and fragility fracture events in adult patients with transfusion-dependent beta-thalassaemia. Serum sclerostin could serve as a marker of severe osteoporosis in beta-thalassaemia patients.
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| Keywords: | Sclerostin beta-thalassaemia bone mineral density fracture events |
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