Candida albicans and candidalysin in inflammatory disorders and cancer |
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Authors: | Jemima Ho Giorgio Camilli James S. Griffiths Jonathan P. Richardson Nessim Kichik Julian R. Naglik |
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Affiliation: | 1. Centre for Host‐Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King''s College London, London UK |
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Abstract: | As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases. |
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Keywords: |
Candida albicans
candidalysin gut barrier IL‐17 mucosal disease |
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