Galectin-3 is a potential biomarker to insulin resistance and obesity in women with polycystic ovary syndrome |
| |
| Authors: | Michelle T. Alves Isabella D. P. de Souza Cláudia N. Ferreira Ana Lúcia Cândido Mariana F. Bizzi Flávia R. Oliveira |
| |
| Affiliation: | 1. Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;2. Colégio Técnico, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;3. Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;4. Maternidade Odete Valadares – Funda??o Hospitalar do Estado de Minas Gerais, Belo Horizonte, Brazil |
| |
| Abstract: | AbstractPolycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder that affects women in reproductive age. This study aimed to evaluate Gal-3 levels and its role on metabolic parameters in women with PCOS. Gal-3 was measured in 44 PCOS and 25 women recruited as control group for the case-control study. Gal-3 levels were similar between PCOS and control groups (p?>?0.05), but showed a positive correlation with glucose levels in the oral glucose tolerance test (OGTT) (r?=?0.403, p?=?0.037), body mass index (BMI) (r?=?0.469, p?=?0.027), insulin levels (r?=?0.453, p?=?0.030) and HOMA-IR (r?=?0.738, p?=?0.037) in PCOS group. The data suggest that Gal-3 plays a role in the pathophysiology of the insulin resistance and obesity in PCOS group. |
| |
| Keywords: | Polycystic ovary syndrome galectin-3 obesity insulin resistance glucose |
|
|
