High dose of d-chiro-inositol improves oocyte quality in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial |
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Authors: | Nicolas Mendoza Maria Isabel Galan Cristina Molina Raquel Mendoza-Tesarik Cristina Conde Maryna Mazheika |
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Institution: | 1. Department of Obstetrics and Gynecology, University of Granada, Granada, Spain;2. nicomendoza@telefonica.net;4. Clinica MARGEN, Granada, Spain |
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Abstract: | AbstractThe aim of this study was to evaluate the effect of two doses of d-chiro-inositol (DCI) in combination with Myo-inositol (MYO) on the oocyte quality (OQ) of women with polycystic ovarian syndrome (PCOS) undergoing intracytoplasmic sperm injection (ICSI). Methods: This was a controlled, randomized, double-blind, parallel group study on 172 oocytes from 11 women. The study compared the effect of two MYO-DCI formulations given over 12?weeks on OQ. Five women received 550?mg of MYO + 300?mg of DCI daily (high DCI content group), while 6 women were given a daily dose of 550?mg of MYO with the only 27.6?mg of DCI (low DCI content group). Results: According to a multivariate analysis using linear mixed effect models, high doses of DCI have a positive influence on the quality of the cytoplasm of the oocyte (β?=?1.631, χ2?=?7.347, d.f.?=?1, p?=?.00672). Zona pellucida, plasma membrane, cytoplasm, and sperm reception have also been improved with any combination of MYO/DCI by decreasing testosterone or improving insulin sensitivity, regardless of age and body mass index. Conclusion: The combination of MYO with high doses of DCI improved oocyte cytoplasm quality in women with PCOS undergoing ICSI. |
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Keywords: | d-chiro-inositol" target="_blank">d-chiro-inositol PCOS ICSI oocyte quality |
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